A screening method for grouper iridovirus protective antigen

A technology of protective antigen and iridescent virus, which is applied in the field of vaccine biology, can solve the problems such as the absence of grouper iridescent virus genetic engineering vaccine and the lack of protective antigen of iridescent virus, so as to reduce time and cost, improve survival rate and The effect of farming efficiency

Inactive Publication Date: 2011-12-14
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there has been no report of a genetically engineered vaccine against grouper iridescent virus
Moreover, for the research on iridovirus vaccines, most researchers are limited to a few protective antigens, and lack a comprehensive understanding of the protective antigens of iridoviruses

Method used

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  • A screening method for grouper iridovirus protective antigen
  • A screening method for grouper iridovirus protective antigen
  • A screening method for grouper iridovirus protective antigen

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Embodiment Construction

[0025] The present invention will be further described below in conjunction with accompanying drawings and examples.

[0026] Material

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Abstract

The present invention relates to a method for screening protective antigens of grouper iridescent virus (SGIV), specifically the identification of protective antigen genes from grouper iridescent virus with vaccine development prospects, including bioinformatics analysis and DNA vaccine identification. Protective antigens were screened out by challenge after preparation and immunization. The present invention provides three protective antigen genes screened out from SGIV162 virus-encoded genes, and provides a method for analyzing and screening potential vaccine candidate antigens in virus-encoded genes, which is beneficial to the further development of new grouper iridescent The virus vaccine can effectively prevent and control grouper iridescent virus disease, and improve the survival rate and breeding efficiency of grouper.

Description

technical field [0001] The invention belongs to the field of vaccine biotechnology, and in particular relates to a method for screening protective antigens of grouper iridescent virus. Background technique [0002] Grouper meat is delicious and has high protein content. It is a kind of edible fish with high economic value, and it is also an excellent fish species that earns foreign exchange in my country. However, in recent years, with the expansion of breeding scale and the deteriorating breeding environment, various diseases, especially viral diseases, frequently broke out, causing significant economic losses. Iridescent virus is an important pathogen of grouper. It can cause fish mortality ranging from 30% (in adults) to 100% (in juvenile stages). In Asia, especially when the water temperature is above 22°C, this virus is very easy to infect rare seawater fish cultured in China, Japan and Southeast Asia, such as grouper, barramundi, red sea bream, flounder and kingfish....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/34C12N15/10A61K48/00A61K39/12A61P31/20
Inventor 欧阳征亮秦启伟汪沛然黄晓红
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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