A kind of application of ginsenoside

A technology for ginsenosides and osteoporosis, applied in the field of application of ginsenosides in the preparation of drugs for the treatment of glucocorticoid-induced osteoporosis, can solve problems that have not been reported, and achieve the purpose of enhancing the curative effect of hormones and reducing osteoporosis , the effect of broadening the scope of medicinal

Inactive Publication Date: 2011-12-21
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0009] Therefore, there is an urgent need for a substance and its application that can play a curative effect on glucocorticoid-induced osteoporosis, but there is no report about this substance and its application

Method used

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  • A kind of application of ginsenoside
  • A kind of application of ginsenoside
  • A kind of application of ginsenoside

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Experimental materials

[0020] Experimental reagents: ginsenoside (purchased from Shanghai Drug Control Institute), DMSO solution, dexamethasone sodium phosphate injection (Dex, provided by Shanghai No. 1 Pharmaceutical Factory).

[0021] Experimental animals: 50 3-month-old female Wister rats, weighing about 150 g (provided by the Experimental Animal Center of Second Military Medical University).

[0022] 2. Experimental method

[0023] (1) Animal modeling and grouping

[0024] After adaptive feeding for 7 days, the mice were randomly divided into 5 groups: normal control group (NC) with 10 mice, model group (glucocorticoid-induced osteoporosis model) (Dex) (the mice were fed with Dex 0.1mg / 100g subcutaneous injection once a day for 8 weeks), 10 rats, 30 rats in the ginsenoside treatment group (GS+Dex) (GS 100 mg / kg in the high-dose group, 50 mg / kg in the middle-dose group, Low dose group 25 mg / kg).

[0025] (2) Experimental steps

[0026] The experiment laste...

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Abstract

The invention relates to an application of ginsenoside in the preparation of medicine for treating osteoporosis, and the osteoporosis is glucocorticoid-induced osteoporosis. The advantages of the present invention are: the present invention provides a new application of ginsenosides, which broadens the medicinal scope of ginsenosides; At the same time, it can effectively prevent and treat glucocorticoid-induced osteoporosis, and reduce the osteoporosis caused by hormone therapy in patients; Better treatment for patients with steroid-induced osteoporosis.

Description

technical field [0001] The present invention relates to the application of a kind of ginsenoside, specifically, the application of a kind of ginsenoside in the preparation of the medicine for treating glucocorticoid-induced osteoporosis. Background technique [0002] Ginsenoside (ginsenoside, GS) is a sterol compound, and ginsenoside mainly exists in Panax genus medicinal materials. Ginsenoside is one of the main active ingredients of ginseng, and it is the main physiologically active substance of ginseng root. Ginsenosides are triterpene dammarane ring derivatives composed of thirty carbon atoms, which have a steroid ring-like structure similar to glucocorticoids. Ginsenosides are considered to be the active ingredients in ginseng and thus have been the subject of research. Because ginsenosides affect multiple metabolic pathways, their efficacy is also complex, and the efficacy of various ginsenosides is difficult to separate. [0003] The preparation method of ginsenosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P19/10
Inventor 吕祥凌昌全杜娟程彬彬李勇
Owner SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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