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Application of curcumin derivative in preparation of medicines for resisting diabetes and complication thereof

A technology of curcumin derivatives and diabetes, which is applied in the fields of application, food preparation, drug combination, etc., can solve the problems that have not been reported in the literature, and achieve the improvement of glucose tolerance, reduction of fasting blood sugar and glycated hemoglobin, steatosis and atherosclerosis The effect of reducing hard lesions

Active Publication Date: 2013-03-20
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Majeed et al disclosed the patent (U.S.Patent, US 7,521,580) that this compound is used for the treatment of cystic fibrosis, but (1E, 6E)-1,7-bis(3,5-di-tert-butyl-4-hydroxyphenyl ) Whether hepta-1,6-diene-3,5-dione has the effect of preventing and treating diabetes and its complications has not been reported in the literature so far

Method used

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  • Application of curcumin derivative in preparation of medicines for resisting diabetes and complication thereof
  • Application of curcumin derivative in preparation of medicines for resisting diabetes and complication thereof
  • Application of curcumin derivative in preparation of medicines for resisting diabetes and complication thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Curcumin derivative (1E,6E)-1,7-bis(3,5-di-tert-butyl-4-hydroxyphenyl)hept-1,6-diene-3,5-dione (hereinafter referred to as L3 ) on glucose and lipid metabolism in hyperlipidemic diabetic mice

[0035] 1.1 Establishment of hyperlipidemia diabetic mouse model

[0036] After 1 week of adaptive feeding of all mice, 18 mice were randomly selected as the normal control group, and the rest were modeled. One day before modeling, all mice were fasted overnight, and streptozotocin was dissolved in 0.1 mol / L citric acid-sodium citrate buffer (pH 4.2) to prepare a solution with a concentration of 0.5% by weight. The treatment group was intraperitoneally injected with 50 mg / kg body weight, once every other day for a total of 5 times, and the normal control group was intraperitoneally injected with an equal volume of citric acid-sodium citrate buffer. After 5 injections, one week apart, fasting overnight, blood was collected from the tail, fasting blood glucose was measured by a fa...

Embodiment 2

[0059] Curcumin derivative (1E,6E)-1,7-bis(3,5-di-tert-butyl-4-hydroxyphenyl)hept-1,6-dien-3,5-dione (L3) pair Influence of Vital Organ Complications in Hyperlipidemic Diabetic Mice

[0060] 2.1 Establishment of hyperlipidemia diabetic mouse model

[0061] Same as 1.1 method.

[0062] 2.2 Drug intervention and detection of indicators

[0063] Animal grouping and administration are the same as in 1.1. The mice were sacrificed for 4 weeks and 16 weeks after administration, and the pancreas, liver, bilateral kidneys, heart, thoracic aorta and abdominal aorta of the mice were isolated, rinsed with cold saline, blotted dry with filter paper, and the liver and kidneys were weighed, respectively. Calculate body mass index. The thoracic aorta and abdominal aorta were fixed with 4% paraformaldehyde solution by weight, and the liver and kidney were fixed with 10% neutral formaldehyde solution by weight. The liver and aorta were embedded in paraffin, sectioned, and stained with conv...

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Abstract

The invention discloses application of a curcumin derivative to preparation of medicines for resisting diabetes and complication thereof and in particular relates to application of (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone to preparation of medicines, health-care products and food for preventing and treating diabetes and complication thereof. The (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone can obviously reduce serum, liver triglyceride, total cholesterol and low-density lipoprotein of high fat feed and streptozotocin induced diabetes model mice, can reduce fasting blood glucose and glycated hemoglobin of the model mice, can improve glucose tolerance of the model mice, can obviously improve glycometabolism and lipid metabolism of the diabetes model mice, and can obviously reduce fatty degeneration of liver and aortic arch and lesion of atherosclerosis.

Description

technical field [0001] The present invention relates to a curcumin derivative (1E, 6E)-1,7-bis(3,5-di-tert-butyl-4-hydroxyphenyl)hept-1,6-diene-3,5-bis Application of ketones in the preparation of medicines and health care products for the prevention and treatment of diabetes and its complications. Background technique [0002] Diabetes is the third leading cause of human death, with more than 200 million patients worldwide and nearly 20 million in my country. In recent years, the incidence of diabetes has been increasing year by year, seriously affecting people's lives and even endangering their lives. [0003] Diabetes causes prolonged hyperglycemia, causing sugar, fat, protein and secondary vitamin, water, electrolyte metabolism disorders, often complicated by atherosclerosis, microvascular disease, nervous system disease, etc., resulting in multiple systems and multiple organs. damage to the device. During the development of diabetes, the incidence of chronic complica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P3/10A61P3/06A61P9/10A61P1/16A23L1/29A23L1/30A23L33/00
Inventor 许建华郑斌刘洋温彩霞
Owner FUJIAN MEDICAL UNIV
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