Process for producing sulfadimidine

A technology for sulfamethazine and production process, applied in the field of sulfamethazine production technology, can solve the problems of waste of raw materials, increase of raw material costs, waste of tail gas hydrogen chloride and no recycling and utilization, etc., so as to reduce neutralization costs, ensure quality and process The effect of conditional optimization

Inactive Publication Date: 2012-01-04
SUZHOU WUGAN PHARMA
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering the process of producing these types of medicinal liquids in the overall chemical plant, the use of acetic acid needs to be purchased, and hydrochloric acid, which has the same neutralizing effect, is produced as tail gas hydrogen chloride gas in the production process; if only acetic acid is used as

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Process for producing sulfadimidine
  • Process for producing sulfadimidine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] figure 1 A kind of sulfamethazine production technology shown in , take sulfamidine and acetylacetone as raw material, carry out condensation reaction in the first step, make wet product sulfamethazine after condensation, the second step washes with hot water and makes wet Product sulfamethazine, remove other incidentals in the reaction solvent, the 3rd step, add gac and liquid caustic soda in the sulfamethazine after washing and carry out alkali-soluble decolorization treatment, the 4th step, for the sulfamethazine after the decolorization The liquid caustic soda taken out of the pyrimidine is neutralized with an acidic solvent, and then crystallized. In the fifth step, the crystallized sulfamethazine is separated out by centrifugal analysis and dried to obtain a finished product, which is characterized in that: the neutralization 1. In the crystallization step, the neutralization of the acidic solvent used is hydrochloric acid neutralization.

[0012] In order to en...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a process for producing sulfadimidine. Sulfaguanidine and acetylacetone are taken as raw materials; and the process comprises the following steps of: 1, performing condensation reaction to obtain a wet product of sulfadimidine; 2, washing with hot water to obtain a wet product of sulfadimidine, and removing other inclusions in a reaction solvent; 3, adding active carbon and caustic soda liquid into the washed sulfadimidine and performing alkali dissolution decoloration; 4, neutralizing caustic soda liquid brought by the decolored sulfadimidine by using an acid solvent, and crystallizing; and 5, separating out crystallized sulfadimidine by adopting a centrifugal analysis method, and drying to obtain a finished product. The process is characterized in that: in the neutralizing and crystallizing step, the acid solvent neutralization is hydrochloric acid neutralization. In the whole chemical production, hydrochloric acid is taken as a byproduct and can be recycled massively; and the hydrochloric acid replaces the conventional acetic acid neutralization solvent, which is more economic, and the quality of the obtained product is improved.

Description

technical field [0001] The invention relates to a production process of sulfamethazine among sulfa products. Background technique [0002] Sulfamethazine is insoluble in water and ether, and has the effect of treating hemolytic coccus, meningococcus and pneumococcus. In the technical process of preparing sulfamethazine, acetic acid is used as the liquid caustic soda remaining in the neutralization and crystallization process and the reaction in the previous step. Considering the process of producing these types of medicinal liquids in the overall chemical plant, the use of acetic acid needs to be purchased, and hydrochloric acid, which has the same neutralizing effect, is produced as tail gas hydrogen chloride gas in the production process; if only acetic acid is used as neutralizing And pharmaceuticals, the market price of acetic acid is higher than hydrochloric acid, not only greatly increased the cost of raw materials, but also wasted the tail gas hydrogen chloride in th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D239/69
Inventor 施方浩
Owner SUZHOU WUGAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap