Process for producing sulfadimidine

Abstract

The invention relates to a process for producing sulfadimidine. Sulfaguanidine and acetylacetone are taken as raw materials; and the process comprises the following steps of: 1, performing condensation reaction to obtain a wet product of sulfadimidine; 2, washing with hot water to obtain a wet product of sulfadimidine, and removing other inclusions in a reaction solvent; 3, adding active carbon and caustic soda liquid into the washed sulfadimidine and performing alkali dissolution decoloration; 4, neutralizing caustic soda liquid brought by the decolored sulfadimidine by using an acid solvent, and crystallizing; and 5, separating out crystallized sulfadimidine by adopting a centrifugal analysis method, and drying to obtain a finished product. The process is characterized in that: in the neutralizing and crystallizing step, the acid solvent neutralization is hydrochloric acid neutralization. In the whole chemical production, hydrochloric acid is taken as a byproduct and can be recycled massively; and the hydrochloric acid replaces the conventional acetic acid neutralization solvent, which is more economic, and the quality of the obtained product is improved.

Description

technical field [0001] The invention relates to a production process of sulfamethazine among sulfa products. Background technique [0002] Sulfamethazine is insoluble in water and ether, and has the effect of treating hemolytic coccus, meningococcus and pneumococcus. In the technical process of preparing sulfamethazine, acetic acid is used as the liquid caustic soda remaining in the neutralization and crystallization process and the reaction in the previous step. Considering the process of producing these types of medicinal liquids in the overall chemical plant, the use of acetic acid needs to be purchased, and hydrochloric acid, which has the same neutralizing effect, is produced as tail gas hydrogen chloride gas in the production process; if only acetic acid is used as neutralizing And pharmaceuticals, the market price of acetic acid is higher than hydrochloric acid, not only greatly increased the cost of raw materials, but also wasted the tail gas hydrogen chloride in th...

AI Technical Summary

Problems solved by technology

Considering the process of producing these types of medicinal liquids in the overall chemical plant, the use of acetic acid needs to be purchased, and hydrochloric acid, which has the same neutralizing effect, is produced as tail gas hydrogen chloride gas in the production process; if only acetic acid is used as neutralizing And pharmaceuticals, the market price of acetic acid is higher than that of hydrochloric acid, which not only greatly increases the cost of raw materials, but also wastes the tail gas hydrogen chloride in the real chemical production process without recycling, which is also a waste of raw materials

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