Traditional Chinese medicine oral solution for prevention and treatment of avian colibacillosis and preparation method of same

A technology of poultry colibacillosis and traditional Chinese medicine oral liquid, which is applied in the field of poultry disease prevention and control, can solve the problems of odor, irritation, hygroscopicity and increased chemical activity, no effect, short intestinal tract of poultry, etc., to avoid drug resistance , easy absorption, rapid onset of effect

Inactive Publication Date: 2012-02-08
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Veterinary drug manufacturers produce according to the Pharmacopoeia and cannot flexibly change the actual situation in poultry production
At the same time, there are many types of traditional Chinese medicines in prescribed prescriptions, and the prices are high, which limits the use of traditional Chinese medicines.
[0008] Traditional Chinese medicines for poultry are mostly powders, but because the specific surface of the medicine is larger after being crushed, its smell, taste, irritation, hygroscopicity and chemical activity also increase accordingly, making some medicines easy to change; volatile components easily lost
When farmers use it, if

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh the Chinese herbal medicine according to 25 parts by weight of Astragalus membranaceus, 25 parts by weight of Radix Astragali, 20 parts by weight of Pulsatilla Radix, 15 parts by weight of Fangfeng, and 15 parts by weight of Poria cocos; , a total of 100g of raw medicinal materials, 100g of Chinese medicinal materials for reflux extraction. A total of 2 extractions, the first time adding 10 times the weight of water (i.e. 1000g water), reflux extraction for 1.5 hours, filtered; the second time, 8 times the weight of water (i.e. 800g water), reflux extraction for 1 hour, filtration, the filtrate Stand overnight, combine twice back flow to extract gained filtrate, filtrate is concentrated to 100ml, add ethanol and make ethanol concentration in filtrate reach 70%, static precipitation, get supernatant and concentrate, reclaim ethanol to no alcohol smell, add correctives (such as weight percent 0.6% stevioside), adjust the Ph value to 5 with 2mol / L Hcl, adjust the tot...

Embodiment 2

[0019] The antibacterial test of "Shuanghuang" oral liquid was carried out in vitro by tube-and-disk method and micro-broth method. The in vitro drug susceptibility test adopts the tube-and-dish method to prepare a culture medium containing E. coli, then place a stainless steel tube on the surface of the culture medium, carefully add 1g / ml drug solution into the steel tube with a dropper, and then put it in a 35°C constant temperature incubator Incubate for 18-24 hours to observe the results. And measure the size of the inhibition zone with a vernier caliper, repeat the measurement 3 times, and take the average value. Judgment criteria are based on the antibacterial zone diameter ≥ 19mm as highly sensitive; 14-19mm as moderately sensitive; 10-14mm as low-sensitivity; ≤10mm as drug-resistant. The micro broth method is used to determine the minimum inhibitory concentration. First, the drug solution is diluted to 1000mg / ml-3.9mg / mL. Under sterile conditions, use a 96-microwell r...

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Abstract

The invention discloses a traditional Chinese medicine oral solution for the prevention and treatment of avian colibacillosis and a preparation method of the same. The preparation method comprises the following steps of: refluxing and extracting Chinese herbal medicines for two times, wherein, for the first time, water is added into the Chinese herbal medicines by weight 10 folds more than the later, the Chinese herbal medicines are refluxed and extracted for 1.5 hours, and are filtered; and for the second time, water is added into the Chinese herbal medicines by weight 8 folds more than the later, the Chinese herbal medicines are refluxed and extracted for 1 hour, and are filtered, filtrate is stewed overnight; combining filtrate refluxed and extracted at the two times; concentrating thefiltrate; adding ethanol to precipitate the filtrate; concentrating supernate; recovering the ethanol to have no alcohol flavor; adding a flavoring agent; adjusting the pH value to 5; adjusting the total volume by using water for injection, equivalent to 1g/mL raw herbs; uniformly mixing the solution; and filling and sterilizing the solution. In consideration of special physiological structures of a short genital tract and incapability of digesting wood fiber of poultry, the medicine is prepared into the oral solution, can be administered to sick poultry in a manner of drinking water, gavage,mixing with feed, is convenient, and is favorable for absorption; and the purpose of quickly taking effect can be achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine oral liquid for preventing and treating poultry colibacillosis and a preparation method thereof, belonging to the technical field of poultry disease prevention and control. Background technique [0002] Avian colibacillosis is a common disease caused by Escherichia coli, characterized by pericarditis, perihepatitis, air sac inflammation, peritonitis, salpingitis, synovitis, E. coli granuloma and omphalitis, etc. lesion. Escherichia coli is a common bacterium in the intestinal tract of healthy livestock and poultry, which can be divided into two categories: pathogenic and non-pathogenic. Escherichia coli disease is a conditional disease, which is easily caused by poor sanitation and poor feeding and management. Escherichia coli has strong resistance to the environment, and Escherichia coli attached to feces, soil, dust in pens, fluff of incubators, broken egg skins, etc. can survive for a long ti...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P31/04
Inventor 舒刚赵小玲符华林林居纯张伟吕程
Owner SICHUAN AGRI UNIV
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