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Decolouring method applied in antibiotic solvent extraction technology

An antibiotic and extraction technology, which is applied in the field of decolorization, can solve the problems of complex process, large product loss, and long production time, and achieve the effects of simplifying the purification process steps, reducing the cost of three wastes treatment, and saving production costs

Active Publication Date: 2014-12-31
濮阳泓天威药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process method has large investment, complicated process flow, long production time and large product loss.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the extract decolorization method of maduramicin mainly comprises the following steps:

[0018] (1) Filtrate the Madumicin fermentation liquid through a plate frame to obtain 2400 kg of filter cake, transfer the filter cake to the extraction tank, add 3000 liters of ethyl acetate extractant to the tank, and start stirring for extraction.

[0019] (2) After 1 hour of extraction, take a sample and measure the transmittance of the extract to be 40%. Add 5kg of activated carbon into the extraction tank to start stirring and decolorization, stir for another 1 hour, and let it stand for 0.5 hours. Transfer the extract to the extract storage by vacuum. inside the tank.

[0020] (3) Then add 2,800 liters of ethyl acetate to the extraction tank for secondary extraction, stop the next extraction when the extraction rate of maduramicin is greater than 90%, and only add activated carbon during the first extraction during the entire extraction process , can meet the d...

Embodiment 2

[0027] Embodiment 2: the extract decolorization method of maduramicin mainly comprises the following steps:

[0028] (1) Filtrate the Madumycin fermentation liquid through a plate frame to obtain 2000 kg of filter cake, transfer the filter cake to an extraction tank, add 2500 liters of ethyl acetate extractant to the tank, and start stirring for extraction.

[0029] (2) Extract for 1 hour, take a sample to test the transmittance of the extract to 38%, add 15kg of acid clay to the extraction tank, stir for 1 hour to decolorize, let stand for 0.5 hours, and transfer the extract to the extract storage tank with vacuum.

[0030] (3) Add 2,000 liters of ethyl acetate to the extraction tank for second extraction, and the extraction rate of dumicin ammonium is 92% (greater than the specified standard of 90%), and the next extraction will not be performed.

[0031] (4) The relationship between the decolorization effect and the dosage of the decolorization and post-extraction decoloriz...

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Abstract

The invention relates to a decolouring method applied in an antibiotic solvent extraction technology. The decolouring method provided by the invention comprises the following main steps of: transferring a solid phase obtained by filtering a broth into an extraction pot, adding an extractant according to a certain proportion, stirring and extracting for one hour; Adding a decolorant which accounts for 0.1-1% the volume of an extract, followed by stirring, extraction and decolouring for 0.5-1.5 hours, standing for 0.5-1 hour, transferring the upper layer of the extract into an extract storage tank; separating the extract by a separation device, and allowing a qualified extract to enter into the next process. According to the invention, the decolouring process is transferred from a post-treatment to a preliminary treatment during the purification process, and the extraction is carried out when decolouring, thus minimizing the equipment investment and simplifying the purification technological steps. Much of the decolorant is adhered to the solid phase substance during the decolouring process, which is beneficial to process the waste solid phase substance and minimize the ''three wastes'' treatment cost. In addition, the decolouring method provided by the invention can be used to minimize the purification time, raise work efficiency, create a good decolouring effect and save the production cost.

Description

technical field [0001] The invention relates to a decolorization method, in particular to a decolorization process suitable for extracting liquid in solid-liquid solvent extraction of antibiotics. Background technique [0002] Solvent extraction is a commonly used method in the purification process of antibiotics and is widely used. The extract produced by solvent extraction generally needs to be decolorized. There are two commonly used antibiotic decolorization process routes: one is extraction, separation, concentration, salt conversion, decolorization, filtration, and crystallization, and the other is extraction, separation, decolorization, filtration, concentration, salt conversion, and crystallization (see "Antibiotics Technology", edited by Wu Xingyan. Chemical Industry Press). This process requires adding a decolorizing agent into a special decolorizing tank for decolorization, and then using a filter to separate the decolorizing agent from the extract. This techno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B63/00C07H1/08C07H17/04
Inventor 郭燕军王新红王德玉黄振锋周超张永旺尤敏
Owner 濮阳泓天威药业有限公司