Pramipexole hydrochloride slow release tablet and preparation method thereof

A technology for pramipexole hydrochloride and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problem of increasing process complexity, increasing prescription complexity, and increasing High manufacturing costs and other issues, to achieve the effect of being suitable for large-scale industrial production and promotion, reducing adverse reactions, and reducing difficulty

Active Publication Date: 2012-04-11
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This increases the complexity of the formulation and increases the manufacturing cost
Moreover, the sustained-release tablet described in

Method used

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  • Pramipexole hydrochloride slow release tablet and preparation method thereof
  • Pramipexole hydrochloride slow release tablet and preparation method thereof
  • Pramipexole hydrochloride slow release tablet and preparation method thereof

Examples

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Effect test

Example Embodiment

[0023] [Example 1] The prescription composition of a sustained-release pramipexole hydrochloride tablet

[0024]

Example Embodiment

[0025] [Example 2] Optimized prescription composition of a sustained-release pramipexole hydrochloride tablet

[0026]

Example Embodiment

[0027] [Example 3] Optimized prescription composition of a sustained-release pramipexole hydrochloride tablet

[0028]

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Abstract

The invention discloses a component formula and a preparation method of a pramipexole hydrochloride slow release tablet. The pramipexole hydrochloride slow release tablet can be continuously and stably released in vivo, is free from influence of pH value change of gastrointestinal tract environment, and only needs to be taken once every day. The preparation method is simple and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pramipexole hydrochloride tablet and a production process thereof. technical background [0002] Oral sustained-release preparations can stabilize blood drug concentration, reduce peak-to-valley fluctuations, and help reduce drug side effects, especially for drugs with a narrow therapeutic window, which can ensure their safety and effectiveness; Maintain within the effective therapeutic concentration range for a long period of time, and for drugs with short half-lives, the frequency of administration can be reduced. [0003] Pramipexole hydrochloride refers to the monohydrate of pramipexole containing two hydrochloric acid molecules, the chemical formula is C 10 h 17 N 3 S 2HCl H 2 O, with a molecular weight of 211.32, is used for the treatment of Parkinson's disease (Parkinson's disease), which is common in the elderly. Parkinson's disease is a degene...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/428A61K47/38A61P25/16
Inventor 李宁王志国盛荣潘卫三
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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