Method for doping amino-reactive dye in silicon dioxide nano-particles

A technology of silica and nanoparticles, which is applied in the field of fluorescent nanomaterials, can solve the problems of low doping efficiency and achieve the effects of improving doping efficiency, improving doping efficiency, and high-efficiency doping

Inactive Publication Date: 2012-05-02
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved in the present invention is to propose a high-efficiency doping method o

Method used

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  • Method for doping amino-reactive dye in silicon dioxide nano-particles
  • Method for doping amino-reactive dye in silicon dioxide nano-particles
  • Method for doping amino-reactive dye in silicon dioxide nano-particles

Examples

Experimental program
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Embodiment 1

[0019] Embodiment 1: Preparation of silica nanoparticles (1)

[0020] Add 100mL of ethanol, 4mL of ammonia water, 2mL of water, and 5mL of TEOS into a 250mL three-necked bottle, and react in a water bath at 40°C for 12 hours under mechanical stirring at a stirring speed of 150rpm. particle.

Embodiment 2

[0021] Embodiment 2: Preparation of silica nanoparticles (2)

[0022] Add 100mL of ethanol, 16mL of ammonia water, 4mL of water, and 10mL of TEOS into a 250mL three-necked bottle, and react in a water bath at 40°C for 12 hours under mechanical stirring at a stirring speed of 150rpm. After centrifugal purification, silica nanoparticles with an average particle size of 200nm particle.

Embodiment 3

[0023] Embodiment 3: Amino modification of the surface of silica nanoparticles (1)

[0024] Disperse 1.34g of silica nanoparticles prepared according to Example 1 in a mixture of 100mL ethanol, 4mL ammonia water, and 2mL water, add 80μl APS, react in a water bath at 40°C for 8 hours, stir at a speed of 200rpm, and obtain after centrifugal purification Amino-modified silica particles with an average particle size of 40nm.

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Abstract

The invention discloses a method for doping an amino-reactive dye in silicon dioxide nano-particles, belonging to the technical field of flourescent material. The technique comprises the processes of an amino-modification for the surfaces of silicon dioxide nano-particles, a covalent coupling for a dye, and a coating for silicon dioxide shell layers. Silicon dioxide seed particles efficiently coupled with a dye on the surfaces thereof are obtained via a seed coupling method, then the seed particles are added in a pre-hydrolyzed system, and the coating for the silicon dioxide shell layers of the seed particles is realized via the rapid aggregation of oligomers and primary particles in the system on the surfaces of the seed particles. In the invention, an efficient coupling for a dye on the surfaces of silicon spheres is realized by separately carrying out the hydrolysis processes for TEOS (tetraethyl orthosilicate) and APS (ammonium persulfate), and the falling-off of the dye is reduced by means of rapidly coating silicon layers via a pre-hydrolysis, so that a purpose of efficiently doping an amino-reactive dye in silicon dioxide nano-particles is realized.

Description

Technical field: [0001] The invention belongs to the technical field of fluorescent nanometer materials, in particular to an efficient doping method of amino active dyes in silicon dioxide nanoparticles. Background technique: [0002] Dye-doped silica nanoparticles have high photostability, are not prone to photodegradation or photobleaching, and silica has good biocompatibility as a medium, and the surface is easy to be functionalized. Therefore, dye-doped silica nanoparticles have broad application prospects in the field of biotechnology. Amino reactive dyes (fluorescein isothiocyanate (FITC), tetramethylrhodamine isothiocyanate (TRITC, tetramethylrhodamine isothiocyanate), 5-carboxyrhodamine 6G succinimidyl ester (5-carboxyrhodamine 6G, succinimidyl As a commonly used commercial dye, it has a high quantum yield and is a very common dye in the field of biotechnology. At present, amino reactive dyes are usually mixed with silane coupling agents (such as APS) Mixed into si...

Claims

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Application Information

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IPC IPC(8): C09K11/06C09K11/02
Inventor 杨文胜徐建全梁经纶薛峥郑惟时李军
Owner JILIN UNIV
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