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Test bed for realizing fuse of nuclear magnetic resonance imaging and in-vivo visible light three-dimensional imaging of animal

A nuclear magnetic resonance image and three-dimensional image technology, applied in the fields of application, medical science, sensors, etc., can solve the problem of high cost of fluorescent labeling, and achieve the effect of low cost, high spatial resolution, and accurate spatial positioning

Inactive Publication Date: 2012-05-09
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

The fusion of NMR images and in vivo visible light images theoretically requires dual-labeled probes that can be imaged in NMR systems and visualized in in vivo visible light imaging systems. The cost of labeling is also very expensive (up to several thousand yuan per milliliter)

Method used

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  • Test bed for realizing fuse of nuclear magnetic resonance imaging and in-vivo visible light three-dimensional imaging of animal
  • Test bed for realizing fuse of nuclear magnetic resonance imaging and in-vivo visible light three-dimensional imaging of animal
  • Test bed for realizing fuse of nuclear magnetic resonance imaging and in-vivo visible light three-dimensional imaging of animal

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Embodiment Construction

[0014] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0015] Such as figure 1 , figure 2 , image 3 As shown, the main body of the present invention is an experimental bed 1 for carrying small animals, and the material is plexiglass. Can be mounted seamlessly on the small animal NMR vibrating bed without compromising the centering of the small animal relative to the coil.

[0016] There are four marker holes 2, 3, 4, and 5 on the bed body, and nuclear magnetic resonance markers are encapsulated in the holes, so that the four marker holes can be imaged in small animal nuclear magnetic resonance, and the nuclear magnetic resonance markers used will not affect small animals. Signal.

[0017] 6 is a series of small diameter holes, which are used as penetration holes for transmitting fluorescent excitation light. In order to avoid the light path change caused by directly penetrating the plexiglass.

[0018] 7,8,9,10,1...

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Abstract

The invention relates to a test bed for realizing fuse of a nuclear magnetic resonance imaging and an in-vivo visible light three-dimensional image of an animal. The test bed comprises a test bed body and an animal fixing device arranged on the test bed body, the test bed body is provided with a marker hole on which a nuclear magnetic resonance imaging marker is packaged, and the test bed body is also provided with a penetrating hole for fluorescence transmission and three-dimensional imaging. According to the invention, the marker on the marker hole can be captured by a nuclear magnetic resonance imaging system and an in-vivo visible light three-dimensional imaging system, and thus the fuse of a nuclear magnetic resonance imaging and an in-vivo visible light three-dimensional image of an animal can be realized.

Description

technical field [0001] The invention relates to a small animal experimental bed, which is used for the fusion of nuclear magnetic resonance images of small animals and three-dimensional visible light images in vivo. Background technique [0002] Bioluminescence imaging (bioluminescence) and fluorescence imaging (fluorescence) are emerging visible light imaging technologies in vivo in recent years. It can non-destructively and real-time monitor the activities and responses of labeled cell tissues in small living animals, and has great application potential in tumor detection, gene expression, protein molecular detection, drug receptor localization, drug screening and drug efficacy evaluation, etc. With the continuous development of imaging technology and detection instruments, it has gradually developed from plane two-dimensional imaging to three-dimensional three-dimensional imaging. Three-dimensional imaging technology has made great progress in the spatial positioning...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00A61B5/055A61B5/00A61B90/00
Inventor 陈春晓王睿杨伟吴佳妮滕皋军
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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