Biliary excretion experimental animal model and building method
A technology of experimental animals and bile excretion, applied in the field of life sciences, to achieve the effect of simple operation process and high success rate
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[0018] The present embodiment utilizes the guinea pig bile excretion research model established by the present invention, which is suitable for preclinical pharmacokinetic research of drugs, and the specific method for establishing the model is as follows:
[0019] 1. 6 healthy guinea pigs, half male and half male, weighing 300-400g;
[0020] 2. Preparation of animal models:
[0021] (1) After the guinea pig was anesthetized (20% urethane, 1.2g / kg, i.p.), it was fixed on the fixed plate in the supine position, and the abdominal hair above and below the xiphoid process was shaved clean with a razor. After routine disinfection, use a scalpel to incise the skin longitudinally on the midline of the abdomen with the xiphoid process as the center point (the incision length is 2.5-3.0 cm). Use ophthalmic tweezers to lift the abdominal muscles, and cut the abdominal muscles with 14cm straight pointed surgical scissors. The length of the incision is about 2.5cm; Push and compress the...
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