Biliary excretion experimental animal model and building method

A technology of experimental animals and bile excretion, applied in the field of life sciences, to achieve the effect of simple operation process and high success rate
CN102440848AInactive Publication Date: 2012-05-09TIANJIN INSTITUTE OF PHARMA RESEARCH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2012-05-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a biliary excretion experimental animal model and a building method, belonging to the technical field of life science. A guinea pig is selected as an animal model; the gall bladder of the guinea pig is ligatured so that the bile directly enters into the common bile duct instead of being stored in the gall bladder after being secreted from the liver. The common bile duct is intubated so that the bile is drained to a 5ml of centrifuge tube for follow-up analysis. The model operation process is simple and quick and has high success rate; and the biliary excretion experimental animal model is an ideal experimental animal model for researching biliary excretion as far as the biotechnology medicine, such as interferon, etc and experimental animal model taking guinea pig as medical activity.
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Description

technical field

[0001] The invention belongs to the technical field of life sciences, and in particular relates to a bile excretion experimental animal model and a method for establishing it. Background technique

[0002] Bile excretion is one of the most important ways for most drugs and their metabolites to be excreted outside the kidney. Many important substances in the body, such as vitamins A, D, E, sex hormones, and thyroid hormones, are significantly excreted through bile. Drugs and metabolites with a molecular weight above 300 and polar groups are mainly secreted from the liver and excreted in the bile. The rate and degree of biliary excretion are affected by the physicochemical properties of the drug (molecular weight, chemical structure, polarity, etc.) and certain biological factors (animal species, age, sex, bile flow, drug biotransformation process, etc.). At the same time, due to the enterohepatic circulation of drugs in the body, the study of bile excretion ...

Claims

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