Method for simultaneously extracting polysaccharides and saponins from astragalus

A technology of astragalus and polysaccharide, applied in the field of medicine, can solve problems such as waste of traditional Chinese medicine resources, and achieve the effects of saving resources, shortening production cycle, and overcoming single product

Inactive Publication Date: 2012-05-09
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the development of traditional Chinese medicinal materials of Astragalus is mostly concentrated on the single component extraction of Astragalus polysaccharides or saponins in Astragalus medicinal materials, resulting in a waste of traditional Chinese medicine resources. It is made into various preparations to guid

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  • Method for simultaneously extracting polysaccharides and saponins from astragalus

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Experimental program
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Effect test

Embodiment 1

[0012] Take 300g of astragalus decoction pieces, put them in a reflux extraction tank, add distilled water to decoct 4 times, decoct with 12 times the amount of water (soaked for 0.5h) for 2 hours for the first time, decoct for 1.5 hours with 8 times the amount of water for the second time, and decoct for 1.5 hours with 8 times the amount of water for the second time Decoct with 6 times the amount of water for 1 hour for the third time, and decoct for 1 hour with 6 times the amount of water for the fourth time, combine the decoction liquid, filter, concentrate the filtrate to 1 g of the original medicinal material per ml, and precipitate with ethanol to make the The alcohol content reaches 70%, refrigerate overnight at 4°C, filter, take the precipitate I and the filtrate I separately, and set aside, the precipitate I is repeatedly washed with ethanol, and dried under reduced pressure at 30-40°C to obtain the extract of astragalus polysaccharide; the filtrate I is recovered Conc...

Embodiment 2

[0014] Take 500g of astragalus decoction pieces, put them in a reflux extraction tank, add distilled water to decoct 3 times, decoct for 2 hours with 10 times the amount of water (soaked for 1 hour) for the first time, decoct for 1.5 hours with 8 times the amount of water for the second time, and decoct for 1.5 hours with 8 times the amount of water for the third time. Decoct with 8 times the amount of water for 1 hour each time, combine the decoction liquid, filter, concentrate the filtrate to 1 g of the original medicinal material per ml, precipitate with ethanol to make the alcohol content reach 75%, refrigerate overnight at 4°C, filter, respectively Take the two parts of the precipitate I and the filtrate I, set aside, wash the precipitate I repeatedly with ethanol, and dry it under reduced pressure at 30-40°C to obtain the extract of astragalus polysaccharide; recover the ethanol from the filtrate I and concentrate it to the equivalent of 10g of the original medicinal mater...

Embodiment 3

[0016] Take 1000g of astragalus decoction pieces, put them in a reflux extraction tank, add distilled water to decoct 3 times, decoct with 10 times the amount of water (soaked for 2 hours) for 2 hours for the first time, decoct for 2 hours with 8 times the amount of water for the second time, and decoct for 2 hours with 8 times the amount of water for the third time Decoct with 6 times the amount of water for 1 hour each time, combine the decoction liquid, filter, concentrate the filtrate to 1 g of the original medicinal material per ml, precipitate with ethanol to make the alcohol content reach 80%, refrigerate overnight at 4°C, filter, respectively Take the two parts of the precipitate I and the filtrate I, set aside, wash the precipitate I repeatedly with ethanol, and dry it under reduced pressure at 30-40°C to obtain the extract of astragalus polysaccharide; recover the ethanol from the filtrate I and concentrate it to the equivalent of 10g of the original medicinal material...

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Abstract

The invention relates to a method for simultaneously extracting polysaccharides and saponins from astragalus. The method comprises the following purifying steps of: decocting and extracting herbal pieces of astragalus root with hot water; cooling a filtrate and concentrating; adding absolute ethyl alcohol (95 percent) for precipitating; performing suction filtration; repeatedly washing; and drying under reduced pressure, and the like. In the method, polysaccharides are precipitated out, and saponin substances are left in an ethanol liquid and treated with macroporous resin or normal butanol to obtain a crude total saponin extract. In comparison to an alcohol extraction method, the method disclosed by the invention has the advantages that: polysaccharides and saponin substances can be extracted out together, resources are saved, the production cost is reduced, and the defects of single products, high energy consumption and the like are overcome. The method has the advantages of high compatibility of an extraction process, simple process, low energy consumption, saving in resources, reduction in the production period and environmentally-friendly production process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a method for separating effective components of Chinese herbal medicines, in particular to a method for simultaneously extracting polysaccharides and saponins from Radix Astragali. Background technique [0002] Radix Astragalus (Radix Astragalus) is the dried root of Astragalus membranaceus or Astragalus membranaceus of the leguminous plant. It is an important traditional Chinese medicine for invigorating Qi. Slightly warm, it has the effect of nourishing qi and tonifying deficiency. It can be used raw or broiled. Astragalus polysaccharides and astragalus saponins are the two main active ingredients of Astragalus membranaceus. They have the functions of strengthening the immune system, resisting diseases, enhancing physical fitness, anti-oxidation, delaying aging, improving heart function, anti-virus, and anti-cancer. Its medicinal effect is remarkable. It has a long history and ...

Claims

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Application Information

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IPC IPC(8): C08B37/00C07J53/00
Inventor 孙博航段立军高慧媛吴立军
Owner SHENYANG PHARMA UNIVERSITY
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