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Strychnine detection material prepared by using bifunctional monomers

A technology of functional monomer, strychnine, applied in the field of food additive testing, can solve problems such as poisoning, convulsions, and strong toxicity of strychnine

Inactive Publication Date: 2012-05-09
成都市龙泉驿区十陵禽业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Strychnine is highly toxic, overdose or improper use can easily cause poisoning and convulsions

Method used

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  • Strychnine detection material prepared by using bifunctional monomers

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Accurately weigh 1 g of the functional monomer allyl-β-cyclodextrin (synthesized by the method in the literature "Chemical Reagents, 2002, 24 (3), 131-132; 138") and dissolve 0.2 mmol of the template molecule strychnine in In 50ml of dimethyl sulfoxide (DMSO), mix at room temperature for 12h to allow the functional monomers to fully interact with the template molecules, then add 5mmol of the crosslinking agent ethylene glycol dimethacrylate (EGDMA) and 20mg of the initiator azobisiso Butyronitrile (AIBN), degassed by ultrasonic for 10 minutes, blown nitrogen for 10 minutes, sealed under vacuum, and polymerized in an air bath at 60°C for 48 hours to obtain a molecularly imprinted polymer.

[0022] The molecularly imprinted polymer was pulverized and then ground and sieved, and the particles between 400 mesh and 500 mesh (particle size 30.8-38.5 μm) were collected, and the fine powder was removed by suspension and sedimentation with acetone for many times. Disperse 1.5g o...

Embodiment 2

[0026] The preparation method of embodiment 2 is similar to that of embodiment 1, except that the functional monomer used in the preparation is methacrylic acid, and the molar ratio of its template molecule: functional monomer: crosslinking agent is: 1:4:25. Its selectivity factor α is 1.34.

Embodiment 3

[0028] The preparation method of embodiment 3 is similar to that of embodiment 1, except that 0.8 mmol of functional monomer methacrylic acid is added during preparation. Its selectivity factor α is 2.52.

[0029] It can be seen that the use of bifunctional monomers can significantly increase the recognition effect.

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Abstract

The invention provides a strychnine molecular imprinting polymer and its preparation method, the method comprises the following steps: dissolving the functional monomers and the template molecule strychnine in dimethyl sulfoxide, mixing for 6-24 hours at room temperature, then adding a cross-linking agent ethylene dimethacrylate and an initiator, performing ultrasonic degassing, introducing nitrogen for deoxygenation, sealing and carrying out thermal-initiated polymerization, cleaning and removing the template molecule, wherein the functional monomers contain allyl-beta-cyclodextrin and methacrylic acid. According to the invention, the molecular recognition capability of the beta-cyclodextrin and the molecular recognition capability of the molecular imprinting technology are used for preparing the strychnine molecular imprinting polymer, the proportion of various raw materials are optimized to obtain good recognition effect. The modification of the beta-cyclodextrin has large influence on its molecular recognition effect, therefore allyl which possesses small structure modification to the beta-cyclodextrin can be selected and introduced to a polymerizable unit, and dual recognition capability of the beta-cyclodextrin and the molecular imprinting technology can be fully used to increase the recognition capability. The bifunctional monomers and a plurality of recognition modes are used for raising the recognition capability further.

Description

technical field [0001] The invention belongs to the field of food additive detection, in particular to the detection of strychnine by molecular imprinting technology. Background technique [0002] Strychnine has a highly selective excitatory effect on the spinal cord, which can increase the excitement of spinal cord reflexes, excite the medullary center, increase breathing and increase blood pressure. In veterinary medicine, it is mainly used for the treatment of central insufficiency paralysis. Strychnine is highly toxic, and overdose or improper use can easily cause poisoning and convulsions. In order to monitor the quality and safety of breeding input feed, it is necessary to detect strychnine in the feed. [0003] Molecular imprinting technology is a technology for preparing polymers with molecular recognition ability. The preparation of molecularly imprinted polymers generally requires three processes: (1) the interaction between the imprinted molecule (recognized su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F290/10C08F222/14C08F220/06C08J9/26
Inventor 陈大友
Owner 成都市龙泉驿区十陵禽业合作社
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