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Avermectin suspension concentrate and preparation method thereof

A technology of abamectin and water suspension, which is applied in the field of abamectin water suspension and its preparation, and can solve problems such as instability and no development of abamectin water suspension

Inactive Publication Date: 2012-05-16
NORTH CHINA PHARMA GROUP AINO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the original drug of Abamectin itself has hydrolysis characteristics and is unstable in water, no water suspension of Abamectin has been developed yet.

Method used

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  • Avermectin suspension concentrate and preparation method thereof
  • Avermectin suspension concentrate and preparation method thereof
  • Avermectin suspension concentrate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare Abamectin aqueous suspension according to the following formula:

[0031] Abamectin original drug: …………………………………………… 10%

[0032] Dispersant (alkyl naphthalene formaldehyde condensate sulfonate): 2%

[0033] Dispersant (polyoxyethylene lauryl ether sulfate): …………………… 1%

[0034] Wetting agent (polyoxyethylene polyoxypropylene ether copolymer): …………………… 2%

[0035] Ethylene glycol: ………………………………………………… 5%

[0036] Xanthan gum: ……………………………………………………… 0.1%

[0037]Silicone defoamer: ……………………………………………… 0.2%

[0038] Stabilizer AX-7: …………………………………………… 1.0%

[0039] Light stabilizer (titanium dioxide, zinc oxide): ……………………… 1.0%

[0040] Silica: ……………………………………………………………………………………………3%

[0041] Water …………………………………………………………………………… Top up

[0042] Put all the materials into the sand mill according to the formula ratio, and stir for 10 minutes at a low speed (100-1000 rpm) to make the materials evenly mixed. Add sanding beads (glass beads or zirconium beads are gener...

Embodiment 2

[0044] Specifically, the mass fraction of abamectin is 0.1%; the mass fraction of the dispersant is 1%, and the alkylnaphthalene formaldehyde condensate sulfonate is selected; the mass fraction of the wetting agent is 1%, and the alkylphenol polyoxyethylene ether is selected; The fraction is 5%, choose ethylene glycol; the mass fraction of viscosity regulator is 0.25%, choose xanthan gum; the mass fraction of stabilizer is 0.1%, choose AX-7; the mass fraction of light stabilizer is 0.1%, choose titanium dioxide; Silicone defoamer, mass fraction 0.2%; filler mass fraction 5%, select white carbon black; deionized water to make up to 100%. Prepare according to the method in formula example 1.

Embodiment 3

[0046] Abamectin mass fraction 1%; dispersant mass fraction 2%, select alkylnaphthalene formaldehyde condensate sulfonate; wetting agent mass fraction 2%, select alkylphenol polyoxyethylene ether; antifreeze agent mass fraction 5% , use ethylene glycol; viscosity modifier mass fraction 0.25%, select xanthan gum; stabilizer mass fraction 0.5%, select AX-7; light stabilizer mass fraction 0.5%, select titanium dioxide; defoamer select organic silicon Foaming agent, mass fraction 0.2%; filler mass fraction 5%, choose white carbon black; deionized water to make up to 100%. Prepare according to the method in formula example 1.

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Abstract

The invention provides an avermectin suspension concentrate, comprising 0.1-50 wt% of avermectin crude drug, 1-3 wt% of dispersant, 1-5 wt% of wetting agent and 0.1-3 wt% of stabilizing agent. Avermectin is an insecticide and acaricide variety from natural antibiotic and is prepared into an environment-friendly suspension concentrate, which can maintain excellent insecticidal activity and satisfy environmental protection demands.

Description

technical field [0001] The invention relates to a preparation using a macrolide compound abamectin as an active ingredient and a preparation method thereof. Background technique [0002] Abamectin, derived from natural antibiotics, is a macrolide compound. It has long been widely accepted and used because of its high efficiency and broad spectrum, easy degradation, no residue, and safety to natural enemies. From 0.2% to 5%, the dosage form includes emulsifiable concentrate, microemulsion, wettable powder, water dispersible granule, etc. Currently, the active ingredient has not been registered in the form of water suspension. [0003] The most common dosage form of abamectin preparation products is emulsifiable concentrate, which is made by dissolving abamectin original medicine in an organic solvent, and then adding a series of auxiliary agents such as surfactants and mixing evenly. The appearance is a homogeneous transparent liquid. A large amount of organic solvents are e...

Claims

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Application Information

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IPC IPC(8): A01N25/04A01N43/90A01N25/22A01P7/04A01P7/02
Inventor 王志亭李涛
Owner NORTH CHINA PHARMA GROUP AINO
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