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Preparation method of ephedrine and furacilin nasal drops

A technology for nasal drops and furosemide is applied in the field of medicine to achieve the effects of improving pH value, improving stability and improving product quality

Active Publication Date: 2015-07-22
WUXI JIYU SHANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention mainly aims at the above-mentioned pH value drop problem, and proposes a method for adjusting the pH value in the production process of furama nasal drops

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: in the furama nasal drop liquid preparation that has added antiseptic; Add the sodium acetate of 0.03% (g / ml) and make it fully dissolve, measure pH value, then adjust pH value to 6.0~7.5, add Add water for injection to the full amount, stir evenly, filter, and seal.

[0014] Embodiment 2: In the furama nasal drop preparation liquid that has added antiseptic; Add the sodium citrate of 0.05% (g / ml) and make it fully dissolve, measure pH value, then adjust pH value to 6.0~7.5 , add water for injection to the full amount, stir well, filter, and seal.

[0015] Embodiment 3: in the furama nasal drop preparation liquid that has added preservative; Add the disodium hydrogen phosphate of 0.06% (g / ml) and make it fully dissolve, measure pH value, then adjust pH value to 6.0~7.5 , add water for injection to the full amount, stir well, filter, and seal.

[0016] Embodiment 4: in the furama nasal drop preparation liquid that has added preservative; Add the disodium ...

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PUM

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Abstract

The invention discloses a preparation method of ephedrine and furacilin nasal drops, and particularly relates to a method for adjusting the pH value of the nasal drops in the production process of ephedrine and furacilin nasal drops. The method is characterized in that: during preparation of the ephedrine and furacilin nasal drops, a pH value buffering agent is added, and the pH value is adjusted to a required range. The falling value of the pH value of finished ephedrine and furacilin nasal drops prepared with the method is small, the pH value tends to keep stable in a falling process, and product quality is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for adjusting the pH value of the nasal drop during the production of the furama nasal drop. Background technique [0002] The main active ingredients of Fuma Nasal Drops are ephedrine hydrochloride and nitrofurazone, which can shrink the blood vessels of the nasal mucosa when used in the nose, so it can be used as a nasal decongestant to relieve nasal congestion, edema, and nasal congestion. [0003] Nitrofuralin can interfere with the sugar metabolism process and oxidase system of bacteria to exert antibacterial or bactericidal effect, mainly interfere with the early stage of bacterial sugar metabolism, leading to bacterial metabolic disorder and death. It has a wide antibacterial spectrum, has antibacterial effects on a variety of Gram-positive and negative bacteria, and has an effect on anaerobic bacteria. It is ineffective against fungi and molds, but ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/345A61K47/02A61K47/12A61P11/02A61K31/137
Inventor 俞婷
Owner WUXI JIYU SHANHE PHARM CO LTD