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Surgical anti-adhesion flushing liquid

An anti-adhesion and flushing solution technology, which is applied in the field of medicine, can solve the problems of short retention time, affecting the wide application of sodium hyaluronate gel, and small amount of clinical use.

Inactive Publication Date: 2012-07-11
SHANGHAI TREEFUL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] However, due to the high content of sodium hyaluronate gel, high viscosity, and small amount of clinical use, it has short retention time in the body and other shortcomings, which to a certain extent have affected the wide application of sodium hyaluronate gel in the field of anti-adhesion.

Method used

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  • Surgical anti-adhesion flushing liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of sodium hyaluronate anti-adhesion flushing solution

[0033] Preparation of 0.1% sodium hyaluronate anti-adhesion flushing solution

[0034] 1. In a 100-grade purification environment, weigh 10 grams of sodium hyaluronate and 85 grams of sodium chloride in 3000 ml of water for injection, shake 1-2 times a day, dissolve for 7 days, and make concentrated sodium hyaluronate solution A;

[0035] 2. In a 100-grade purification environment, add water for injection filtered through a 0.22-micron filter to the A solution until the total amount of the medicinal solution is 10 liters, stir to dissolve evenly, and make a B solution;

[0036] 3. In a 100-grade purification environment, filter the B solution with a 0.22 micron filter;

[0037] 4. Pack the above-mentioned filtered medicinal liquid into polyvinyl chloride plastic bags, 2000ml / bag, and seal with a transfusion plug;

[0038] 5. In a 100-level purification environment, seal t...

Embodiment 2

[0054] Embodiment 2: Preparation of sodium hyaluronate-glycine anti-adhesion flushing solution

[0055] Preparation of 0.03% Sodium Hyaluronate-3.0% Glycine Anti-adhesion Washing Solution

[0056] 1. In a 100-grade purification environment, weigh 3.0 grams of sodium hyaluronate and 300 grams of glycine and dissolve them in 3000 ml of water for injection, shake 1-2 times a day, dissolve for 7 days, and make concentrated solution A;

[0057] 2. In a 100-grade purification environment, add water for injection filtered through a 0.22-micron filter to the solution A to a total of 10 liters, and fill with nitrogen (pressure 0.2 MPa ~ 0.25 MPa). Stir to dissolve for 30 minutes to make the solution uniform.

[0058] 3. Glacial acetic acid adjusts the pH value to 5.5-6.0;

[0059] 4. The liquid medicine is filtered through a filter element of 0.22 microns (polypropylene);

[0060] 5. Pack the above-mentioned filtered medicinal liquid into polyvinyl chloride plastic bags, 200...

Embodiment 3

[0079] Embodiment 3: Preparation of sodium hyaluronate-glucose anti-adhesion flushing solution

[0080] Preparation of 0.03% sodium hyaluronate-5.0% glucose anti-adhesion flushing solution

[0081] 1. In a class 100 purification environment, weigh 3.0 grams and 500 grams of sodium hyaluronate, dissolve them in 3000 ml of water for injection, shake 1-2 times a day, dissolve for 7 days, and make a concentrated solution A;

[0082] 2. In a 100-grade purification environment, add water for injection filtered through a 0.22-micron filter to 10 liters of solution A, and heat (at a temperature of 70°C to 80°C). Stir and dissolve for 30 minutes, and cool to 25°C to 30°C after fully dissolving.

[0083] 3. The liquid medicine is filtered through a folded filter element of 0.22 microns (polypropylene);

[0084] 4. Pack the above-mentioned filtered medicinal liquid into polyvinyl chloride plastic bags, 2000ml / bag, and seal with a transfusion plug;

[0085] 5. In a 100-level pu...

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Abstract

The invention relates to surgical anti-adhesion flushing liquid, which belongs to the technical field of medicine. The surgical anti-adhesion flushing liquid is prepared from sodium hyaluronate, medicine water and any one kind of materials of sodium chloride or glycine or glucose or mannite or sorbierite. The surgical anti-adhesion flushing liquid provided by the invention is mainly prepared from the sodium hyaluronate as major effective ingredients, and the surgical anti-adhesion flushing liquid can be used for abdominal adhesion, adhesive ileus and the like after the surgical abdominal operation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an anti-adhesion flushing liquid for surgery. Background technique [0002] With the continuous advancement of modern surgical technology, surgical techniques and methods are also developing rapidly. From the founding of the People's Republic of China to the present, the number of surgical operations in my country has shown a rapid growth trend. In the past, many diseases were treated conservatively. Satisfactory results can be achieved in a short period of time. According to statistics, the number of surgeries nationwide in 2005 was close to 10 million, which shows that the technical level of surgeries has been brought into full play. But for many years, in surgical operations, more than 90% will involve the problem of postoperative tissue adhesion. Adhesion is an abnormal structure formed by combining connective tissue fibrous bands with adjacent tissues or organs due to tissue...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/728A61K33/14A61P41/00A61K31/198A61K31/7004A61K31/047
Inventor 戴永强陈亚玲
Owner SHANGHAI TREEFUL PHARMA
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