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Preparation method and production method of Chuanxiong decoction integrated new formulation

A production method and technology of new dosage forms, applied in the field of preparation of integrated new dosage forms of Chuanxiong Decoction

Inactive Publication Date: 2012-07-11
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, drug plasmids, microcapsules, nanoparticles, nanospheres, nanocapsules, etc., and then mix them and put them into soft and hard capsules at the same time Combined use and preparation of an integrated new dosage form or other types of integrated new dosage forms according to the above method; 2) Research and development of "nano-drug integrated new dosage form" by using nano-carrier combination technology and the theory of integrated traditional Chinese and Western medicine. The product has target It has the characteristics of wide distribution and strong slow and controlled release performance; there is no public report in the domestic literature, and the comprehensive technical characteristics of this project have certain novelty and innovation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0052] The composition of the raw materials used to make the active ingredients is——

[0053] Angelica 10 parts, Chuanxiong 10 parts.

[0054] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0056] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] Angelica 10 parts, Chuanxiong 10 parts.

[0059] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization re...

Embodiment 3

[0061] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0062] The composition of the raw materials used to make the active ingredients is——

[0063] Angelica 10 parts, Chuanxiong 10 parts.

[0064] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The application site: neck, chest, back, abdomen, legs, soles of the feet, Ashi point and othe...

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Abstract

The invention relates to a preparation method and a production method of a Chuanxiong decoction integrated new formulation. The Chuanxiong decoction integrated new formulation comprises the following active ingredient raw materials in part by weight: 10 parts of Chinese angelica and 10 parts of Chuanxiong. The production method of the Chuanxiong decoction integrated new formulation comprises the following steps: supersonic airflow crushing, alcohol water extraction, ultrasonic crushing and extraction, water decoction and concentration, supersonic spray drying, nanometer grinding, high-pressure homogenization, nanoparticle preparation and the like. The preparation method and the production method of the Chuanxiong decoction integrated new preparation pay attention to the advantages of multiple-collaboration, multiple targets and the like embodied by the application of a nano / carrier technology. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting property and the sustained and controlled release property of drugs are stronger. The Chuanxiong decoction integrated new formulation can be internally and externally dosed and can also be taken at four time periods according to a midnight-noon ebb-flow and human body blood flow law. The Chuanxiong decoction integrated new formulation can also be prepared into a film agent and a transdermal agent, respectively stuck at different parts of a human body according to the midnight-noon ebb-flow and human body blood flow law and directly adsorbed by skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Chuanxiong Decoction, and also relates to a preparation technology of a new integrated dosage form of Chuanxiong Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxida...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K9/00A61P15/00A61P7/04A61P1/08A61P25/00A61P27/10A61P27/16
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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