Benzothiazole derivative and application thereof

A technology of benzothiazole derivatives, which is applied in the field of benzothiazole derivatives, can solve the problems of slow brain clearance, postmortem diagnosis, large trauma and risk of biopsy
CN102558091AInactive Publication Date: 2012-07-11HEFEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEFEI UNIV OF TECH
Publication Date
2012-07-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses benzothiazole derivatives represented by general formulas (I)-(II) and pharmaceutically acceptable salts thereof, which have inhibition and developing effects on aggregation and precipitation of amyloid beta-protein. When being used as developers, the benzothiazole derivatives are required to be marked with appropriate radioactive isotopes or contrast agents which are applicable to magnetic resonance detection. The compounds are applied to producing drugs for preventing and treating diseases including Alzheimer's disease, and the developers are applied to aggregates and sediments of amyloid beta-protein.
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Description

1. Technical field

[0001] The present invention relates to a class of bioactive compounds and uses thereof, in particular to a benzothiazole derivative capable of imaging amyloid deposits and inhibiting their aggregation. 2. Background technology

[0002] Alzheimer's disease (AD) is a common neurodegenerative disease, the main clinical manifestations are cognitive dysfunction and memory loss, personality and behavior changes, decreased judgment, loss of self-care ability, etc. human health and quality of life. Currently in developed countries, AD has become the fourth biggest killer after heart disease, tumor and stroke. Brain tissue autopsy confirmed to contain a large number of senile plaques (SPs) formed by the aggregation of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau protein, as well as neuron loss, etc., among the present invention Reference to amyloid deposits includes, but is not limited to, senile plaques.

[0003] ...

Claims

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