Compositions comprising tramadol and celecoxib in the treatment of pain
A technology of celecoxib and its composition, which is applied in the field of treating severe to moderate pain, can solve problems such as the undetermined correlation of ulcer healing, and achieve good blood-brain barrier penetration and pain treatment effects
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[0069] Preparation of composition doses of tramadol hydrochloride and celecoxib
[0070] Preparation of racemic tramadol hydrochloride and celecoxib at different molar ratios (1:1, 1:3 and 3:1) of (racemic)-tramadol·HCl:celecoxib combination. All drugs and combinations were dissolved in distilled water containing 0.5% hydroxypropylmethylcellulose and administered at 10 ml / kg per rat via intraperitoneal (i.p.) route. Table 1 lists the different ratios prepared at various concentrations.
[0071] Table 1. Corresponding doses of each drug or combination administered intraperitoneally
[0072]
[0073] Effects of thermal hyperalgesia in a postoperative pain model in rats
[0074] The aim of this study was to evaluate the elimination of the combination comprising tramadol / celecoxib, in particular at different molar ratios (1:1, 1:3 and 3:1), in a model of postoperative pain following paw incision in rats. Analgesic efficacy and potency of a combination of tramadol hydrochlor...
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