Anti-stroke medicinal composition, tablet and preparation methods thereof

A technology for a composition and medicinal materials, which is applied in the field of traditional Chinese medicine research and development, can solve the problems of large dosage, unclear action mechanism and high cost, and achieve the effects of high pharmacoeconomic significance, good therapeutic effect and low cost.

Active Publication Date: 2012-08-01
湖南天济草堂制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the western medicines used for anti-stroke are mainly thrombolytic drugs and channel blockers, but most of them have considerable side effects, and patients should not take them for a long time, so the long-term treatment effect is not ideal
Traditional Chinese medicine guided by the theory of traditional Chinese medicine not only has the characteristics of stable curative effect,

Method used

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  • Anti-stroke medicinal composition, tablet and preparation methods thereof
  • Anti-stroke medicinal composition, tablet and preparation methods thereof
  • Anti-stroke medicinal composition, tablet and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0048] Example 1

[0049] Preparation process of pharmaceutical composition:

[0050] Put Ligusticum chuanxiong and Angelica sinensis (320g each) into the extraction tank, add 10 times the amount of 70% ethanol for the first time, heat to boiling (about 70°C), keep the heat for extraction for 2 hours, and filter the extract to obtain the first extraction Liquid and solid filter residues are ready for use;

[0051] Add 8 times the amount of 70% ethanol for the second time, continue to extract at 70°C for 1.5 hours, and filter out the extract;

[0052] Combine the two extracts, and concentrate the mixed solution at a temperature of 60°C and a vacuum of 0.06Mpa until there is no alcohol smell to obtain an extract concentrate with a relative density of 1.10-1.30 (60°C) for later use;

[0053] The natural borneol (10g) is added to the above-mentioned extract concentrate and dissolved to obtain the pharmaceutical composition.

Example Embodiment

[0054] Example 2

[0055] Preparation process of pharmaceutical composition:

[0056] Put Ligusticum chuanxiong and Angelica sinensis (320g each) in the extraction tank, add 10 times the amount of 70% ethanol for the first time, heat to boiling (about 80°C), keep the heat for extraction for 2 hours, and filter the extract to obtain the first extraction Liquid and solid filter residues are ready for use;

[0057] Add 8 times the amount of 70% ethanol for the second time, continue to extract at 80°C for 1.5 hours, and filter out the extract;

[0058] Combine the two extracts, and concentrate the mixed solution at a temperature of 65°C and a vacuum of 0.07Mpa until there is no alcohol smell to obtain an extract concentrate with a relative density of 1.10-1.30 (60°C) for later use;

[0059] The natural borneol (10g) is added to the above-mentioned extract concentrate and dissolved to obtain the pharmaceutical composition.

Example Embodiment

[0060] Example 3

[0061] Preparation process of pharmaceutical composition:

[0062] Put Ligusticum chuanxiong and Angelica sinensis (320g each) into the extraction tank, add 10 times the amount of 70% ethanol for the first time, heat to boiling (about 100°C), keep the heat for extraction for 2 hours, and filter the extract to obtain the first extraction Liquid and solid filter residues are ready for use;

[0063] Add 8 times the amount of 70% ethanol for the second time, continue to extract at 100 ° C for 1.5 hours, and filter out the extract;

[0064] Combine the two extracts, and concentrate the mixed solution at a temperature of 70°C and a vacuum of 0.08Mpa until there is no alcohol smell to obtain an extract concentrate with a relative density of 1.10-1.30 (60°C) for later use;

[0065] The natural borneol (10g) is added to the above-mentioned extract concentrate and dissolved to obtain the pharmaceutical composition.

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Abstract

The invention discloses an anti-stroke medicinal composition, a tablet and preparation methods thereof. The method comprises the following steps of: adding 70 percent ethanol into szechuan lovage rhizome and Chinese angelica serving as raw medicinal materials in an amount of 10 times the total amount of the raw medicinal materials for the first time, putting into an extraction tank, extracting atthe temperature of 70-100 DEG C for 2 hours, filtering an extracting solution out to obtain a first extracting solution, and filtering solid filter residues out for later use; adding 70 percent ethanol into the solid filter residues in an amount of 8 times the total amount of the solid filter residues, putting into the extraction tank, extracting at the temperature of 70-100 DEG C for 1.5 hours, filtering an extracting solution out to obtain a second extracting solution and solid residues; mixing the extracting solutions, concentrating the mixed solution under reduced pressure at the temperature of 60-70 DEG C till alcohol taste disappears to obtain an extracted concentrate, wherein the relative density of the concentrate is 1.10-1.30, and the density is measured at the temperature of 60 DEG C; and adding smashed natural borneol into the extracted concentrate for dissolving to obtain a medicinal composition, wherein the medicinal composition comprises the following medical materials in parts by weight: 10-50 parts of szechuan lovage rhizome, 50-10 parts of Chinese angelica and 1-10 parts of natural borneol. The obtained composition plays remarkable a role in repairing impairment of stroke and cranial nerve functions.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and relates to a combination and preparation of anti-stroke drugs. It is specifically composed of Chinese medicinal materials Chuanxiong, angelica and natural borneol. The main active ingredients in the medicinal materials are the total alkaloids of Chuanxiong, the total organic acids of Chuanxiong. Total lactones of chuanxiong, total organic acids of angelica, total lactones of angelica, etc., supplemented with natural borneol as the main medicinal ingredients, are used for the preparation of treatment and prevention of stroke, and are mainly used for the treatment of acute stroke, recovery period and its sequelae, vascular senile dementia, etc. Drugs for hemorrhagic cardiovascular and cerebrovascular diseases. Background technique [0002] Stroke, also known as cerebrovascular accident or cerebral apoplexy, is a type of disease with sudden coma, unconscio...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K9/20A61P9/10
Inventor 翁小涛
Owner 湖南天济草堂制药股份有限公司
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