Extract containing breviscapine and preparation method thereof

A technology of breviscapine and its extracts, applied in the field of preparations, to achieve the effects of abundant resources, reduced damage, and sufficient supply

Inactive Publication Date: 2012-08-01
王祥红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But currently there is only a GAP planti

Method used

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  • Extract containing breviscapine and preparation method thereof
  • Extract containing breviscapine and preparation method thereof
  • Extract containing breviscapine and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0044] The preparation method of the extract of the present invention can use organic solvent or alkali extraction, and acid treatment to obtain a crude extract containing scutellarin, for example, a crude extract containing more than 10% scutellarin can be obtained; For further purification by porous resin separation technology or propanol treatment, a high-purity extract containing scutellarin can be obtained, for example, an extract with a content range of scutellarin greater than 60% can be obtained. The acid used in the preparation method of the present invention includes but is not limited to hydrochloric acid, sulfuric acid, phosphoric acid, carbonic acid or acetic acid, formic acid; the base includes but not limited to sodium hydroxide, potassium hydroxide, ammonium water, arginine, lysine , Histidine, sodium carbonate, sodium bicarbonate, sodium hydrogen phosphate.

[0045] Scutellarin contains scutellarin and a small amount of scutellarin. In the present invention, scut...

Embodiment 1

[0048] Example 1: The fingerprint spectrum of Pterococcus tenuiflora and the content determination of scutellarin

[0049] Preparation of test solution: Take this product, smash through No. 2 sieve, accurately take about 1.0g, add methanol and reflux for extraction 2 times, 50ml each time, 30min, filter, combine the filtrate, evaporate the residue in a water bath, and add 60% Dissolve and dilute with methanol to 10ml, shake well, and pass through a 0.45μm filter membrane to get it.

[0050] Preparation of reference solution: accurately weigh an appropriate amount of scutellarin reference substance dried at 105°C to constant weight, add methanol to make a solution containing 0.2mg per 1ml, and get it.

[0051] Instrument: Agilent 1100 (including quaternary gradient pump, autosampler, column oven, diode array detector)

[0052] Chromatographic conditions:

[0053] Chromatography column: Zorbax SB C18 (4.6×250mm, 5μm)

[0054] Mobile phase: A. 0.5% formic acid, B. acetonitrile, C. methano...

Embodiment 2

[0065] Example 2: Determination of the content of scutellarin in Scabionella

[0066] The method is the same as in Example 1, and the results are shown in Table 1.

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Abstract

The invention discloses an extract containing breviscapine and a preparation method thereof. The extract is derived from a compositae erigeron or conyza plant. The invention particularly relates to an extract containing breviscapine which is prepared by performing process steps such as solvent extraction, separation, concentration, drying and the like on an erigeron plant, i.e., annual fleabane herb and conyza plants such as horseweed herb, conyza sumatrensis and conyza bonariensis serving as raw materials. The extract can be prepared into a plurality of dosage forms such as injections, tablets, capsules and the like together with pharmaceutically-acceptable auxiliary materials. The annual fleabane herb, horseweed herb, conyza sumatrensis and conyza bonariensis are biological invasive plant varieties. Due to the adoption of the annual fleabane herb, horseweed herb, conyza sumatrensis and conyza bonariensis to preparation of breviscapine, the source is extremely wide, a plurality of medicinal values are achieved, damages of the annual fleabane herb and the like on biological diversity can be reduced, harm is converted into benefit, and multiple things are achieved at one stroke.

Description

Technical field [0001] The present invention relates to an extract containing scutellarin, in particular to a preparation of an extract containing scutellarin from a plant of the genus Erigeron of the Compositae family or the genus Dioscutum, a method for preparing the extract, and a preparation prepared using the extract . Background technique [0002] There are more than 200 species of Erigeron in the Compositae, including Erigeron breviscapus (Erigeron breviscapus), Erigeron annuus, Erigeron elongatus Ledeb, Erigeron molle D Don, etc. . The nature is cold, slightly bitter, sweet and warm. It has the effects of dispelling cold and relieving the surface, dispelling wind and dampness, promoting blood circulation and removing blood stasis, reducing inflammation and pain, clearing heat and toxins, resolving phlegm and relieving cough. Clinically, it is mainly used to treat cardiovascular and cerebrovascular diseases and various inflammations. [0003] There are more than 80 specie...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P9/10A61P13/12A61P3/10A61P11/00A61P9/00A61P1/16A61P31/20
Inventor 王祥红
Owner 王祥红
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