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Application of coenzyme Q10 to preparation of medicines for preventing and treating altitude erythrocytosis

A technology of polycythemia and Q10, which is applied in the application field of coenzyme Q10 in the preparation of drugs for the prevention and treatment of high altitude polycythemia, can solve problems that have not been reported, and achieve the effect of improving microcirculation and improving hypoxia tolerance

Inactive Publication Date: 2012-08-15
ARMY MEDICAL UNIV
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  • Application Information

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Problems solved by technology

Studies have shown that coenzyme Q10 has a variety of physiological functions, reducing oxidative damage caused by hypoxia, suggesting that coenzyme Q10 may become an effective hypoxia-resistant drug, but its effect on preventing and treating high-altitude polycythemia has not been seen at home and abroad so far to report

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  • Application of coenzyme Q10 to preparation of medicines for preventing and treating altitude erythrocytosis

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Embodiment Construction

[0009] The application of coenzyme Q10 described in the present invention in the preparation of drugs for the prevention and treatment of high altitude polycythemia, purchase commercially available coenzyme Q10, track healthy men who migrated from plains to plateaus with an altitude of 4300 m, and take coenzyme Q10 orally, 1 capsule each time, 3 times a day The second time, the blood routine was tested before administration, 1 month and 2 months after administration, and the data were statistically analyzed using SPSS13.0 independent sample T.

[0010] The human experiment process and results are as follows:

[0011] Effects of coenzyme Q10 on hematocrit in men who migrated to 4300 m altitude plateau

[0012] At an altitude of 1300 m, Han males who planned to migrate to the plateau (4300 m) were randomly divided into a coenzyme Q10 group (18 people) and a placebo group (20 people). 3 / d, taken continuously for 2 months; the control group (namely the placebo group) also took pl...

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Abstract

The invention discloses application of coenzyme Q10 to preparation of medicines for preventing and treating altitude erythrocytosis. Commercially available coenzyme Q10 is purchased, healthy men migrating from a plain to a plateau with an elevation of 4300m are tracked, and are given with the coenzyme Q10 for orally taking one grain once with three times for one day; the healthy men are administrated with the coenzyme Q10 before and after 1 month and two months, blood routine examination is detected, and data is subjected to statistical analysis by adopting SPSS13.0 independent samples T. According to the invention, the altitude erythrocytosis caused by long-term chronic hypoxia can be effectively prevented and treated, the hypoxia tolerance of a human body can be effectively improved, and the function of improving microcirculation is achieved.

Description

technical field [0001] The invention relates to the new application of existing medicines, in particular to the application of coenzyme Q10 in the preparation of medicines for preventing and treating plateau polycythemia. Background technique [0002] Long-term chronic hypoxia can cause erythrocytosis, which is conducive to improving the oxygen-carrying capacity of the blood flow and improving tissue oxygen supply, which is an effective compensatory response for the body to adapt to the plateau hypoxic environment. However, some people have excessive compensatory hyperplasia of red blood cells, the concentration of hemoglobin exceeds 200 g / L, and RBC≥6.5×10 12 / L, and hematocrit ≥ 65%, it is called high altitude polycythemia [Edited by Li Suzhi. Altitude Diseases, People's Health Publishing House, 2006:70-71]. Therefore, hematocrit is an important indicator for diagnosing plateau polycythemia. Increased hematocrit increases blood viscosity, increases blood flow resistance, ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P7/00
Inventor 罗勇军王福领高钰琪周其全陈郁
Owner ARMY MEDICAL UNIV