Method for determining content and content homogeneity degree of chlorpheniramine maleate in antitussive and expectorant particles

Abstract

The invention discloses a method for determining the content and the content homogeneity degree of chlorpheniramine maleate in antitussive and expectorant particles, comprising the following four steps of: preparing a comparison product solution, preparing a solution of a sample to be tested under a content determination item, preparing a solution of the sample to be tested under a homogeneity degree determination item, and utilizing a high performance liquid chromatography to determine. The method has the advantages that the specially-prepared solution of the sample to be tested is combined with the high performance liquid chromatography so that the method with good stability and repeatability for determining the content and the content homogeneity degree of the chlorpheniramine maleate in the antitussive and expectorant particles is provided for detecting the content and the content homogeneity degree of the chlorpheniramine maleate in the antitussive and expectorant particles; and therefore, the quality detection index of the antitussive and expectorant particles is more comprehensive and the product quality can be better controlled.

Description

technical field [0001] The invention relates to a method for determining the content of pharmaceutical components, in particular to a method for determining the content and uniformity of chlorpheniramine maleate in Shunqi Huatan granules. Background technique [0002] The properties of Shunqi Huatan Granules are light brown to brown granules with a sweet taste and slightly bitter taste. Its functions and indications are: relieving cough and relieving asthma, smoothing Qi and resolving phlegm. For the treatment of flu, acute and chronic bronchitis, cough with phlegm, chest tightness and shortness of breath embolism. The medicinal ingredients are four traditional Chinese medicines of Vitex japonica, pine cone, plantain and licorice, and two chemical medicines of aminophylline and chlorpheniramine maleate. The above six herbs, Vitex japonica, pine cone, plantain, and licorice, are added to decoct twice for 3 hours each time, and the decoctions are combined, left to settle, fil...

AI Technical Summary

Problems solved by technology

[0005] It can be seen from the above that the current quality inspection of Shunqi Huatan Granules includes the identification of aminophylline, chlorpheniramine maleate, and Vitex chrysanthemum in the existing indicators, and the content determination of aminophylline, but there is no content Less chlorpheniramine maleate content and determination of content uniformity, it is impossible to know whether the content of chlorpheniramine maleate in Shunqi Huatan Granules is accurate and uniform, and the product cannot be better controlled quality