Method for determining content and content homogeneity degree of chlorpheniramine maleate in antitussive and expectorant particles

A technology for chlorpheniramine acid, shunqi and phlegm reduction, is applied in the field of determination of drug component content, and can solve the problems of not knowing whether the content of chlorpheniramine maleate is accurate and uniform, and not being able to better control product quality and the like , to achieve comprehensive quality inspection indicators, control product quality, and good repeatability

Inactive Publication Date: 2012-08-22
ZHONGXING PHARM CO LTD JIANGSU
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen from the above that the current quality inspection of Shunqi Huatan Granules includes the identification of aminophylline, chlorpheniramine maleate, and Vitex chrysanthemum in the existing indicators, and the content determination of aminophylline, but

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Below in conjunction with specific embodiment, further illustrate the present invention, should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention, after having read the present invention, those skilled in the art will understand various equivalent forms of the present invention All modifications fall within the scope defined by the appended claims of the present application.

[0020] A method for measuring the content of chlorpheniramine maleate and its uniformity in Shunqihuatan granules, comprising the following steps:

[0021] (1) Preparation of reference substance solution: Take an appropriate amount of chlorpheniramine maleate reference substance, weigh it accurately, add methanol to make a solution containing about 20 μg chlorpheniramine maleate per 1 ml, and obtain it.

[0022] (2) Preparation of the test solution under the item of content determination: take Shu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for determining the content and the content homogeneity degree of chlorpheniramine maleate in antitussive and expectorant particles, comprising the following four steps of: preparing a comparison product solution, preparing a solution of a sample to be tested under a content determination item, preparing a solution of the sample to be tested under a homogeneity degree determination item, and utilizing a high performance liquid chromatography to determine. The method has the advantages that the specially-prepared solution of the sample to be tested is combined with the high performance liquid chromatography so that the method with good stability and repeatability for determining the content and the content homogeneity degree of the chlorpheniramine maleate in the antitussive and expectorant particles is provided for detecting the content and the content homogeneity degree of the chlorpheniramine maleate in the antitussive and expectorant particles; and therefore, the quality detection index of the antitussive and expectorant particles is more comprehensive and the product quality can be better controlled.

Description

technical field [0001] The invention relates to a method for determining the content of pharmaceutical components, in particular to a method for determining the content and uniformity of chlorpheniramine maleate in Shunqi Huatan granules. Background technique [0002] The properties of Shunqi Huatan Granules are light brown to brown granules with a sweet taste and slightly bitter taste. Its functions and indications are: relieving cough and relieving asthma, smoothing Qi and resolving phlegm. For the treatment of flu, acute and chronic bronchitis, cough with phlegm, chest tightness and shortness of breath embolism. The medicinal ingredients are four traditional Chinese medicines of Vitex japonica, pine cone, plantain and licorice, and two chemical medicines of aminophylline and chlorpheniramine maleate. The above six herbs, Vitex japonica, pine cone, plantain, and licorice, are added to decoct twice for 3 hours each time, and the decoctions are combined, left to settle, fil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N30/88
Inventor 张红梅徐冰
Owner ZHONGXING PHARM CO LTD JIANGSU
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap