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Novel mixed bone cement

A new type of bone cement, applied in the fields of medical science, dentistry, dental preparations, etc., can solve the problems of poor compatibility, the occurrence of abrasive disease, and the inability to osseous fusion.

Inactive Publication Date: 2012-09-26
SHANGHAI RUIPING BIOTECH TECH
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. Since the bone cement releases a large amount of heat during the solidification process after being injected into the bone marrow cavity, the residual blood and fat in the bone marrow cavity will expand after being heated, causing the pressure in the marrow cavity to rise, which will cause fat to enter the blood vessel and cause embolism
[0007] 4. The biocompatibility of PMMA bone cement is poor, and its mechanical properties are far from those of autologous bone. Its compressive strength is too high, so it cannot be bony fusion, and it will loosen in the long term, resulting in complications such as wear and tear
At present, the research on "mixed bone cement" has not yet formed an ideal mixed formula

Method used

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Embodiment Construction

[0029] During the clinical process of this project, it was found that 20% "Guyisheng" (TradeMark CEM) (50-60% calcium sulfate, 20-25% hydroxyapatite, 20-25% calcium triphosphate) was added to 80% PMMA The resulting "mixed bone cement" has the characteristics of high viscosity, low fluidity and uniform mixing. In 1991, Qiu Shijing and others mixed decalcified bone particles into bone cement in a certain proportion. Through scanning electron microscope observation, they found that bone particles were connected to each other in many areas to form connected tunnels for bone structure to grow into. At 3 months, a large amount of bone tissue grew into the deep layer of bone cement along the channel formed by bone particles, and lamellar bone structure was visible. The "Gu Yisheng" in this experimental study also has osteoinductive effect, and will not cause rejection with the body. It is very convenient to mix with PMMA, and the feasibility of intraoperative use is higher. Under th...

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Abstract

The invention provides novel mixed bone cement. The novel mixed bone cement provided by the invention provides a strong support for the bone at the initial stage, and gradually the rigidity of PMMA bone cement is decreased with the ingrowth of cancellous bone at the later stage, so that the implant has elastic modulus similar tothe cancellous bone, and has both mechanical and biological fixation, thus long-term complications of PMMA bone cement can be reduced. The characteristics of high viscosity and low liquidity of the mixed bone cement are very important in percutaneousvertebroplasty and percutaneous kyphoplasty (PVP and PKP), and the occurrence of bone cement leakage can be reduced.

Description

Technical field: [0001] The invention relates to the field of medical devices, and more specifically relates to a bone implant material for orthopedics, brain surgery and stomatology, which plays the roles of bone grafting, bone support and bone adhesion. It is used in bone grafting, joint replacement and revision, percutaneous kyphoplasty (PVP and PKP) and other fields. Background technique: [0002] The "bone cement" whose main component is polymethyl methacrylate (PMMA) first appeared in the early 1960s and is a commonly used bone adhesive in orthopedic clinics. PMMA is not uncommon in daily life. Plexiglass is composed of PMMA, which is extremely difficult to be absorbed by the human body. So it's hard to imagine that permanently implanting a piece of plexiglass in the defect wouldn't cause problems, and orthopedic surgeons just kept using it because they couldn't find a better alternative. [0003] Polymethyl methacrylate (PMMA) bone cement is much higher in strength,...

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/16A61K6/083A61K6/033A61K6/027A61K6/838
Inventor 罗平
Owner SHANGHAI RUIPING BIOTECH TECH
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