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Hypoglycemic drug composition and application of hypoglycemic drug composition

A composition and drug technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems of α-glucosidase inhibitor drugs with large side effects, achieve good hypoglycemic effect, and reduce postprandial blood sugar , reduce the effect of toxic and side effects

Active Publication Date: 2012-10-03
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a hypoglycemic pharmaceutical composition to solve the problem of large side effects of α-glucosidase inhibitors

Method used

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  • Hypoglycemic drug composition and application of hypoglycemic drug composition
  • Hypoglycemic drug composition and application of hypoglycemic drug composition
  • Hypoglycemic drug composition and application of hypoglycemic drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Weigh 100g of wood butterfly seeds, after drying, pulverize, cold soak for 48h with 1500ml, 90% ethanol aqueous solution, filter, and obtain the extract;

[0040] ②Under the condition that the water bath temperature is 35°C, after vacuum distillation to remove ethanol, raise the water bath temperature to 60°C, and continue vacuum distillation to remove water to obtain an oil;

[0041] ③ Add 200ml of petroleum ether to the oily substance and soak in cold for 24 hours;

[0042] ④ Centrifuge at 2000r / min for 5min, remove the petroleum ether, and dry at room temperature to obtain a yellow powdery Oxychophylla extract.

Embodiment 2

[0044] ①Weigh 100g of wood butterfly seeds, after drying, pulverize, cold-soak with 2000mL, 75% ethanol aqueous solution for 24h, and filter with suction to obtain a clarified extract;

[0045] ②Under the condition that the water bath temperature is 35°C, after vacuum distillation to remove ethanol, raise the water bath temperature to 60°C, and continue vacuum distillation to remove water to obtain an oil;

[0046] ③Add 300ml of petroleum ether to the oil, and soak for 24 hours;

[0047] ④ Centrifuge at 2000r / min for 5min, remove the petroleum ether, and dry at room temperature to obtain a yellow powdery Oxychophylla extract.

Embodiment 3

[0049] ①Take 100g of wood butterfly seeds, after drying, crush them, use 3000mL of 50% acetone aqueous solution for ultrasonic extraction for 2h, and after suction filtration, obtain a clarified extract;

[0050] ②Under the condition that the water bath temperature is 35°C, after the acetone is removed by vacuum distillation, the water bath temperature is raised to 60°C, and the water bath is continued to be removed by vacuum distillation to obtain an oil;

[0051] ③ Add 100ml of petroleum ether to the oily substance, and soak for 20 hours;

[0052] ④ Centrifuge at 2000r / min for 5min, remove the petroleum ether, and dry at room temperature to obtain a yellow powdery Oxychophylla extract.

[0053] 2. Preparation of Oral Dosage

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Abstract

The invention relates to a hypoglycemic drug composition, which contains alpha-glucosaccharase inhibitor and Indian Trumetflower Seed extract, wherein the Indian Trumetflower Seed extract is prepared by the processes of extracting the Indian Trumetflower Seed with aqueous solution of organic solvent, filtering, re-extracting, separating and drying. The drug composition prepared from the Indian Trumetflower Seed extract and alpha-glucosaccharase inhibitor lower than normal dosage has excellent hypoglycemic effect. The hypoglycemic drug composition has the main advantages that postprandial blood glucose can be reduced faster and more efficiently, and less alpha-glucosaccharase inhibitor is used, so the drug effect can be improved, the toxic and side effects of the alpha-glucosaccharase inhibitor are effectively reduced, and the problems of hypoglycemia and the like easily caused by drug combination are also effectively solved.

Description

technical field [0001] The present invention relates to a pharmaceutical composition obtained by compounding α-glucosidase inhibitors and wood butterfly seed extracts, which can significantly reduce the level of postprandial blood sugar than using α-glucosidase inhibitors alone, and solve the problem of α-glucosidase inhibitors. - Problems such as high dosage of glycosidase inhibitors and relatively large side effects belong to the field of medicine. Background technique [0002] Diabetes is a metabolic disease caused by endocrine disorders, which is extremely harmful to human health. Its metabolic disorders can lead to chronic complications in various tissues such as kidneys, nerves, eyes, and cardiovascular and cerebrovascular tissues. In severe cases, ketoacidosis, coma, etc., and it is easy to cause cross-infection. According to a study published in the authoritative medical journal "The Lancet" in June 2011, there are currently about 347 million diabetic patients in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K36/185A61P3/10A61K31/445A61K31/7036A61K31/133
Inventor 董悦生桑元斌张博崴徐亲民修志龙
Owner DALIAN UNIV OF TECH
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