Sensing chip of dual-detecting biochemical sensing detector and preparation method thereof

A sensor chip, a combined technology, applied in the field of biochemical sensing detection, to achieve the effect of good repeatability, less samples, and accelerated research and development and application

Inactive Publication Date: 2012-10-03
MINZU UNIVERSITY OF CHINA
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Problems solved by technology

[0004] In order to solve the deficiencies in the traditional single testing technology LSPR or SERS technology, using local surface plasmon resonance LSRP technology, microfluidic technology and micro-nano proce

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  • Sensing chip of dual-detecting biochemical sensing detector and preparation method thereof
  • Sensing chip of dual-detecting biochemical sensing detector and preparation method thereof
  • Sensing chip of dual-detecting biochemical sensing detector and preparation method thereof

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Embodiment Construction

[0029] The specific implementation manner of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0030] like figure 1 As shown, the sensor chip of the present invention includes a K*L array sensor chip unit, and the sensor chip unit includes: a substrate 31 and an upper sheet 32 ​​bonded thereto; formed in the upper sheet 32 ​​to form a microfluidic channel Inlet, outlet 33 and microcavity 34; m*n array of nanoparticles 35 formed on the substrate and in the microcavity; wherein, m, n, K and L are natural numbers.

[0031] like Figure 4 As shown, the dual-detection biochemical sensor detector of the present invention includes: a light source system 1, an optical path shaping system 2, a sensor chip 3, a three-dimensional control system 4, a surface-enhanced Raman SERS detection system 5, a localized surface plasmon resonance LSPR Detection system 6; and automatic sample feeding control system 7; wherein, the sensor...

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Abstract

The invention discloses a sensing chip of a dual-detecting biochemical sensing detector and a preparation method thereof. The sensing chip comprises a sensing chip unit arranged in a K*L array, wherein the sensing chip unit comprises a substrate and an upper slice bonded with the substrate together; an inlet, an outlet and a microcavity which are formed in the upper slice to form a micro-flow channel; and nano particles arranged in an m*n array, which are formed on the substrate and located in the microcavity, wherein m, n, K and L are natural number. The sensing chip provided by the invention is a multi-unit and multi-array structure and combined with a micro-flow control technology to integrate a micro-flow control optical sensing system. With the adoption of a nano processing technique with low cost, the sensing chip can be processed on a large area; furthermore, the sensing chip is good in repeatability, simple in preparation method and few in required samples; the sensing chip can observe in real time, perform the parallel test of multiple channels and parameters and the tests of in-situ surface enhanced raman scattering (SERS) and localized surface plasmon resonance (LSPR).

Description

technical field [0001] The invention belongs to the field of biochemical sensing and detection, and relates to a sensor chip of a surface-enhanced Raman spectrum integrated microfluidic optics-localized surface plasmon resonance dual-detection biochemical sensing detector and a preparation method thereof. Background technique [0002] A large number of studies have shown that the optical properties of metal nanoparticles are the localized surface plasmon resonance (LSPR) frequency, which is closely related to the composition, spacing, size, shape and local dielectric environment of metal nanoparticles. Therefore, as a potential spectral analysis technology based on localized surface plasmon sensor chips, it has been widely used in various aspects such as physics, chemistry, medicine, environmental monitoring, and public safety. The shape, size, and spacing of metal nanostructures have an impact on the optical properties of LSPR and the SERS enhancement effect of surface-enha...

Claims

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Application Information

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IPC IPC(8): G01N21/55G01N21/65B81C1/00G01N21/552
CPCG01N21/658G01N21/554
Inventor 耿照新
Owner MINZU UNIVERSITY OF CHINA
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