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Transformable acupoint injection ligustrazine medicine and method for preparing same

A technology of acupoint injection and ligustrazine medicine, which is applied in the field of transformable acupoint injection medicine and its preparation, can solve the problems of non-biodegradation, application limitation and the like, and achieves the effects of simple and easy operation, high compliance and good curative effect.

Inactive Publication Date: 2013-10-09
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Homopolymers and copolymers of isopropylacrylamide and polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymers are typical thermosensitive hydrogels, but they are not biodegradable, which limits their applications.
From the perspective of cross-linking agents, glutaraldehyde or polyvinyl alcohol is used as a physical cross-linking agent, but its application is also limited because of the toxic effects of glutaraldehyde and the allergic reaction of polyvinyl alcohol.

Method used

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  • Transformable acupoint injection ligustrazine medicine and method for preparing same
  • Transformable acupoint injection ligustrazine medicine and method for preparing same
  • Transformable acupoint injection ligustrazine medicine and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]The preparation method of transformable acupoint injection ligustrazine medicine comprises the following steps:

[0035] 1) Dissolve chitosan in 0.1M acetic acid solution to prepare a chitosan acetic acid solution with a concentration of 2.3wt% (mass) (stir with a magnetic stirrer for about 1 hour to fully dissolve it in acetic acid);

[0036] 2) Prepare a dipotassium hydrogen phosphate solution with a concentration of 14.75wt% (mass) with deionized water;

[0037] 3) The above-mentioned chitosan acetic acid solution and dipotassium hydrogen phosphate solution were stored in a refrigerator at 4°C for about 0.5 hours;

[0038] 4) According to the ratio of each raw material: ligustrazine: chitosan acetic acid solution: dipotassium hydrogen phosphate solution = 2mg: 1mL: 1mL, choose ligustrazine, chitosan acetic acid solution and dipotassium hydrogen phosphate solution and mix to obtain Transformable point injection of Ligustrazine drug (sol).

[0039] Application: The tr...

Embodiment 2

[0069] Basically the same as Example 1, the difference is: the concentration of chitosan acetic acid solution is 2wt% (mass). The concentration of dipotassium hydrogen phosphate solution is 14wt% (mass).

[0070] Application: The transformable acupoint injection of ligustrazine drug is currently being used in scientific research and experimental research to observe its effect on MMP-9 and TIMP-1 in the cortical area of ​​focal cerebral ischemia-reperfusion rats. The process and conditions of MMP-9 and TIMP-1 experiments. Effect is the same as embodiment 1.

Embodiment 3

[0072] Basically the same as Example 1, the difference is: the concentration of chitosan acetic acid solution is 2.5wt% (mass). The concentration of dipotassium hydrogen phosphate solution is 15wt% (mass).

[0073] Application: The transformable acupoint injection of ligustrazine drug is currently being used in scientific research and experimental research to observe its effect on MMP-9 and TIMP-1 in the cortical area of ​​focal cerebral ischemia-reperfusion rats. The process and conditions of MMP-9 and TIMP-1 experiments. Effect is the same as embodiment 1.

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Abstract

The invention relates to a transformable acupoint injection ligustrazine medicine and a method for preparing the same. The rotatable acupoint injection ligustrazine medicine is characterized in that the rotatable acupoint injection ligustrazine medicine is formed by mixing ligustrazine, chitosan acetate solution and dipotassium phosphate solution at a ratio of 2 milligrams: 1 milliliter: 1 milliliter. The invention provides a new formulation for treating diseases through injecting medicine to acupoints, which has a better curative effect and high compliance.

Description

technical field [0001] The invention relates to a transformable acupoint injection medicine and a preparation method thereof. Background technique [0002] Chitosan-based thermosensitive gel is a new type of injectable hydrogel that was proposed after 2000. It has good biocompatibility, biodegradability, and no degradation products (oligosaccharides and monosaccharides). toxicity [1-3] . At present, chitosan-based thermosensitive gels are widely used in the research of tissue engineering repair and drug release carriers. [0003] Chitosan hydrogel is commonly used to entrap some sensitive protein drugs such as insulin, or drugs with short biological half-life, unstable oral administration, and relatively large systemic side effects [4-5] , From the analysis of the internal force of the gel, the gel is mainly affected by electrostatic and hydrophobic forces, and there is no strong covalent force and stable structure. Therefore, the drug release is mainly through diffusion ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61K47/36A61K9/00A61K9/06A61P9/10
Inventor 孔立红刘本
Owner HUBEI UNIV OF CHINESE MEDICINE