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Pharmaceutical composition for treating chronic hepatitis B and preparation method and application thereof

A technology for chronic hepatitis B and composition, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve problems such as limited formulation and preparation

Inactive Publication Date: 2014-03-19
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many traditional Chinese medicine preparations for the treatment of hepatitis B on the market, there are limited prescription preparations with significant clinical efficacy. Facing such a large population of hepatitis B patients, it is particularly necessary to develop new Chinese medicine compound preparations that can treat chronic hepatitis B.

Method used

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  • Pharmaceutical composition for treating chronic hepatitis B and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0023] Take 20g of Citrus aurantium, 12g of Bupleurum, 10g of peach kernel, 10g of Salvia miltiorrhiza, 15g of Polygonum cuspidatum, 10g of white peony root, 10g of fried Atractylodes macrocephala, 10g of Poria cocos, add water to decoct 3 times, combine the decoction, concentrate, and then add appropriate amount of dextrin to prepare Granules, that is, granules.

Embodiment 2

[0024] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0025] Citrus aurantium 26g, Bupleurum 8g, peach kernel 7g, salvia miltiorrhiza 7g, Polygonum cuspidatum 10g, white peony root 7g, fried Atractylodes macrocephala 7g, Poria cocos 7g, decoct with water for 3 times, combine decoction, concentrate, add appropriate amount of dextrin, granulate , Tablets, that is, tablets.

Embodiment 3

[0026] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0027] Citrus aurantium 14g, Bupleurum 16g, peach kernel 13g, salvia miltiorrhiza 13g, knotweed 20g, white peony root 13g, fried Atractylodes macrocephala 13g, poria cocos 13g, decoct with water for 3 times, combine decoction, concentrate, dry, add appropriate amount of microcrystalline cellulose , after mixing evenly, pack into capsules to obtain capsules.

[0028] The beneficial effects of the present invention will be specifically described below through test examples.

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Abstract

The invention discloses a pharmaceutical composition for treating chronic hepatitis B, which is a preparation prepared by raw material drugs according to the following weight ratios: 14-26 parts of immature bitter orange, 8-16 parts of bupleurum chinense, 7-13 parts of peach kernel, 7-13 parts of salvia miltiorrhiza, 10-20 parts of giant knotweed rhizome, 7-13 parts of root of herbaceous peony, 7-13 parts of rhizoma atractylodis macrocephalae, and 7-13 parts of poria cocos. The invention also provides a preparation method and an application of the pharmaceutical composition. The clinical study finds that the pharmaceutical composition can obviously improve clinical symptoms, liver function and HBV-DNA (hepatitis B virus-deoxyribonucleic acid) of liver-stagnation with spleen-deficiency type chronic hepatitis B, and has good effects of protecting liver and lowering transaminase and anti-HBV activity, thus providing a new choice for the clinical medication for treating the chronic hepatitis B.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic hepatitis B, a preparation method and application thereof. Background technique [0002] Chronic hepatitis B is one of the common viral hepatitis. It can be transmitted through blood, mother to child, damaged skin and sexual contact. It is also a common chronic infectious disease. According to the report of the World Health Organization (WHO), chronic hepatitis B accounts for the seventh of the top ten causes of death in the world, and 30% of hepatitis B patients will eventually develop liver cirrhosis and liver cancer. In China alone, 300,000 people die of it every year. Diseases caused by HBV infection. [0003] Nucleoside analogues and interferon are currently used to treat hepatitis B and hepatitis B virus carriers. Among them, the more commonly used nucleoside analogues include lamivudine, adefovir lipid, entecavir, telbivudine, tenofovir disoproxil, etc., and their overa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P1/16A61P31/20
Inventor 冯全生范昕建郭尹玲张传涛郑秀丽张之文
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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