Oxygen-containing isotope compound, preparation method, application and composition

A compound and isotope technology, applied in chemical instruments and methods, application of radiation from radioactive sources, inorganic chemistry, etc., can solve the problems of unrealistic compounds, high production costs, short half-lives, etc., and achieve easy availability, low price, and easy operation. easy effect

Inactive Publication Date: 2016-04-27
BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, containing [ 18 The labeled compound of F] is expensive in terms of production cost, and can only be limited to some limited compounds, that is, only certain groups in the compound can be labeled after being replaced by fluorine, carbon, etc.
[0009] In addition, the preparation of labeled compounds by traditional cyclotrons does not use photonuclear reactions, and requires chemical methods to label the prepared isotopes on the compounds
preparation 15 The nuclear reaction formula of O(oxygen-15) is 15 N(p,n) 15 O and 14 N(d,n) 15 O, and, since 15 The half-life of O is extremely short, only 2 minutes, chemically labeled with 15 Compounds of O isotopes are completely unrealistic

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxygen-containing isotope compound, preparation method, application and composition
  • Oxygen-containing isotope compound, preparation method, application and composition
  • Oxygen-containing isotope compound, preparation method, application and composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, irradiate at 50 MeV for 5 minutes, and the irradiation rate is 3000Gy (Ge Rui) / min. After irradiation, the water molecules on the 16 O transforms into 15 O, take 10 μl with 15 After the O water was injected through the tail vein of SD rats (outbred group rats), the water imaging of the lungs and brain could be observed.

[0050] Experiments have shown that in this example, a 15 O water. Please see attached figure 1 , with figure 1 prepared in this example 15 The measured radioactive decay curve (oscillation curve) of O water and 15 A comparison plot of the theoretical decay curves of O. From the comparison chart, it can be seen that 15 The measured radioactive decay curve of O water is 15 Oscillation near the theoretical deca...

Embodiment 2

[0055] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, irradiate at 51 MeV for 5 minutes, and the irradiation rate is 3000Gy (Ge Rui) / min.

[0056] Other steps are identical with embodiment 1. Obtained the experimental effect basically the same as embodiment 1. The obtained PET labeling pattern is also similar, and the effect difference between embodiment 2 and embodiment 1 cannot be distinguished by the naked eye.

Embodiment 3

[0058] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, and irradiate at 49 MeV for 5 minutes at an irradiation rate of 3000Gy (Ge Rui) / min.

[0059] Other steps are identical with embodiment 1. Obtained the experimental effect basically the same as embodiment 1. The obtained PET labeling pattern is also similar, and the effect difference between embodiment 3 and embodiment 1 cannot be distinguished with the naked eye.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an oxygen isotope compound and its preparation method, the application of the oxygen isotope compound in positron or other nuclide imaging, and the distribution of the oxygen isotope compound in the organism after obtaining the oxygen isotope compound or applications in metabolic imaging, compositions comprising the oxygen-containing isotope compound. The preparation method of the compound containing oxygen isotopes is to irradiate water with rays such as x-rays, proton rays, and heavy particle rays produced by high-energy electron accelerators, protons, heavy ions, or neutron therapy equipment, and the energy of the rays is 20 MeV To 430MeV, without destroying the structure of water molecules, the oxygen atoms in the water can generate oxygen positron nuclides through photonuclear reactions, thereby producing compounds containing oxygen isotopes. Using the compound of the present invention in an organism can clearly mark the distribution and metabolism of the compound in the organism. The compound of the present invention can be used in PET, PET-CT, PET-MRI, PET-MRI-CT, mMR and other nuclear medicine equipment.

Description

technical field [0001] The invention relates to an oxygen isotope compound and its preparation method, the application of the oxygen isotope compound in positron or other nuclide imaging, and the distribution of the oxygen isotope compound in the organism after obtaining the oxygen isotope compound or applications in metabolic imaging, compositions comprising the oxygen-containing isotope compound. Background technique [0002] Nuclear medicine examinations, represented by positron emission tomography (abbreviated as PET), scintillation tomography (abbreviated as DS), and single photon emission computed tomography (abbreviated as SPECT), play an important role in diagnosing a variety of diseases, including heart disease and effective in cancer). These techniques involve administering to a patient an agent labeled with a specific radioisotope (abbreviated as a radiopharmaceutical), followed by detection of gamma-rays emitted directly or indirectly from the agent. Compared w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C01B5/00A61K51/00
CPCG21G1/06G21G1/10G21G1/12G21H5/02
Inventor 曾骏张圈世孙启银
Owner BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap