Application of gallocatechin in preparation of drugs for resisting benign prostatic hyperplasia

A technology of gallocatechin and benign prostatic hyperplasia, which is applied in drug combination, urinary system diseases, etc.

Inactive Publication Date: 2012-12-19
CATCH BIO SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report of the monomer compound GC be...

Method used

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  • Application of gallocatechin in preparation of drugs for resisting benign prostatic hyperplasia
  • Application of gallocatechin in preparation of drugs for resisting benign prostatic hyperplasia
  • Application of gallocatechin in preparation of drugs for resisting benign prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Effect of gallocatechin on rat prostate

[0022] 1. Experimental animals

[0023] Male healthy SD (Sprague-Dawley) rats, clean grade, weighing 250±20g, purchased from Shanghai Xipuer-Bikay Laboratory Animal Co., Ltd., certificate number: 00800160568, production license number: SCXK (Shanghai) 2008-0016 .

[0024] 2. Modeling, grouping and administration

[0025] The above-mentioned 35 rats were generally fed for one week to adapt to the environment. After ordinary observation showed no abnormalities, 7 animals were randomly selected as the normal control group, and the remaining 28 animals were used for modeling. After being anesthetized with ether, the skin was routinely disinfected under aseptic conditions, the bilateral testes were removed through the scrotum, the stump was ligated to ensure hemostasis, the skin was sutured, and a certain amount of ofloxacin injection was dripped to prevent infection. Intramuscular injection (im) penicillin 400,000 u / ...

Embodiment 2

[0058] Example 2 Preparation of gallocatechin gallate liposomes

[0059] Dissolve lecithin, cholesterol and gallocatechin in a mixed solution of absolute ethanol and chloroform (the volume ratio of absolute ethanol and chloroform is 1:1, and the total volume is 15ml) in a ratio of 3g: 1g: 0.1g by mass 2 mg vitamin E was added to obtain solution A, an appropriate amount of folic acid 33 mg was dissolved in 330 μl dimethyl sulfoxide to obtain solution B, solutions A and B were mixed and 9 g of lactose was added to obtain mixture C, and the solvent was removed from solution C to obtain a phospholipid film; Dissolve the obtained phospholipid film in water, obtain liposome after hydration, filter the liposome through a 0.2 μm filter membrane, and pressurize the liposome solution step by step in a high-pressure homogenizer under a pressure of 200-400Mpa After homogenizing for 2 hours, the obtained liposomes were a clear and uniform solution. The obtained liposome solution was freez...

Embodiment 3

[0060] Example 3 Preparation of Gallocatechin Capsules

[0061] Prescription: 500g of gallocatechin, 15g of starch, 5g of magnesium stearate (about 0.5%), made into 1000 capsules.

[0062] Preparation: Pass gallocatechin gallate, starch and magnesium stearate through an 80-mesh sieve, mix them evenly, and put them into empty capsules to obtain the product.

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PUM

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Abstract

The invention discloses an application of gallocatechin in the preparation of drugs for resisting benign prostatic hyperplasia. According to the invention, through a prostatic hyperplasia model in ovariectomized rats induced by testosterone propionate, gallocatechin is selected as a therapeutic drug so as to observe the influence on rat prostate weight and index and pathological changes of prostate tissues. Research results show that gallocatechin can significantly reduce the prostate weight and prostate index of the animal model and improve pathological symptoms of prostate tissues.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the new medical application of gallocatechin, in particular to the application of gallocatechin in preparing anti-benign prostatic hyperplasia medicine. Background technique [0002] benign prostatic hyperplasia [1] (benign prostatic hyperplasia, BPH) is a common physiological lesion in elderly men, and its incidence has shown an obvious upward trend in recent years. According to statistics, the incidence rate of the disease in men over 60 years old reaches more than 70%, which seriously affects the health and quality of life of elderly patients. Drugs clinically used to treat BPH mainly include [2] : α1-adrenoceptor antagonists, 5α-reductase inhibitors and natural product preparations, etc. Since natural product preparations have less adverse reactions and are suitable for long-term use, they have attracted widespread attention in recent years. [0003] The structural formula of galloc...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P13/08
Inventor 温尧林李坤
Owner CATCH BIO SCI & TECH
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