Silk fibroin peptide chain-containing AlaGlyAlaGly polyurethane fiber film and preparation method thereof

Abstract

The invention relates to a silk fibroin peptide chain-containing AlaGlyAlaGly polyurethane fiber film and a preparation method thereof, and belongs to the field of functionalized preparation and machining of polyurethane materials. The preparation method comprises the following steps: taking tert-butoxycarbonylation protective amino acid and hexamethylene diisocyanate as raw materials, N-methylmorpholine as alkali, and N,N'-dicyclohexyl carbodiimide and N-hydroxysuccinimide as a compound condensing agent, and preparing silk fibroin characteristic peptide chain-containing double-end primary amine derivatives by adopting a traditional liquid phase polypeptide synthesis method; then taking the double-end primary amine derivatives as a chain extender, reacting with 4,4'-diphenyl-methane-diisocyanate-polytetrahydrofuran prepolymer to synthesize the silk fibroin characteristic peptide chain-containing polyurethane. The silk fibroin peptide chain-containing AlaGlyAlaGly polyurethane fiber film not only contains a microphase separation frame structure of polyurethane, but also embeds polypeptide segments including amino acid residue contained in the silk fibroin in the main chain of a primary structure, thus belonging to the field of peptide chain / non-peptide copolymer imitated biological materials, and having the potential of being used in the biological and medical fields.

Description

technical field [0001] The invention belongs to the field of preparation and processing of functionalized polyurethane materials, and in particular relates to a polyurethane fiber film containing silk fibroin characteristic peptide chain AlaGlyAlaGly and a preparation method thereof. Background technique [0002] In order to obtain bionic fibers whose structure and performance can be compared with silk, in the textile industry, polyester fibers without silk fibroin peptide components are generally treated with alkali to obtain imitation silk [Textile Progress, 1997, 27 (2): 1], To mimic the look and feel of natural silk. However, the structure determines the performance, and the performance of imitation silk with similar chemical structure and condensed matter structure of silk should be closer to it. Therefore, people have conducted extensive and in-depth research on the regeneration of silk fibroin. However, although the primary structure is close to natural silk, the pr...

AI Technical Summary

Problems solved by technology

[0003] Chinese invention patent (CN101905030A) discloses a preparation method of silk fibroin-modified polyurethane medical biomaterial, but does not characterize its aggregate structure

Images