Pramipexole oral liquid and preparation method thereof

A technology of pramipexole and oral liquid, which is applied in the fields of pharmaceutical formulation, drug delivery, nervous system diseases, etc., and can solve the problems that the preparation of pramipexole oral liquid has not been reported.

Inactive Publication Date: 2013-01-02
BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned patents are all pramipexole sustained-release tablets, and there is no report on pramipexole oral liquid preparations

Method used

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  • Pramipexole oral liquid and preparation method thereof
  • Pramipexole oral liquid and preparation method thereof
  • Pramipexole oral liquid and preparation method thereof

Examples

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specific Embodiment

[0016] The pirfenidone tablet prepared by the present invention has a content of 0.2 g of pirfenidone per preparation unit. Specific examples are as follows:

[0017] Material name weight (g) Pramipexole dihydrochloride monohydrate 0.25 Sorbitol 200 citric acid 1.4 sodium citrate 0.7 Acesulfame K 3 sodium benzoate 2 water Appropriate amount

[0018] Preparation process: Weigh the prescribed amount of pramipexole dihydrochloride monohydrate, sorbitol, and acesulfame potassium into appropriate amount of water, add sodium benzoate after dissolving, finally add citric acid, sodium citrate, stir until clear and transparent, and constant volume , filtered and filled in brown plastic bottles.

[0019] Material name weight (g) Pramipexole dihydrochloride monohydrate 0.5 sucrose 200 Sodium dihydrogen phosphate 8.24 sodium hydroxide Appropriate amount Potassium sorbate 2 steviosid...

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PUM

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Abstract

The present invention belongs to the technical field of medicine, and provides a pramipexole oral liquid and a preparation method thereof. Pramipexole is a dopamine D2 receptor agonist for treatment of Parkinson's disease; early symptoms of the Parkinson's disease comprise static tremor, myotonia, bradykinesia, and abnormal posture and gait; and moderate and advanced symptoms of the Parkinson's disease patients often comprise difficult chewing and swallowing. With the pramipexole oral liquid of the present invention, medication compliance of patients is easily improved, and a therapeutic effect is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a pramipexole oral liquid and a preparation method thereof. Background technique [0002] Pramipexole is a dopamine D2 receptor agonist used to treat Parkinson's disease. It is structurally distinct from ergot-derived drugs such as bromocriptine or pergolide. It is also pharmacologically unique in that it is a full agonist and has receptor selectivity for the dopamine D2 family of dopamine receptors. [0003] The chemical name of pramipexole is: (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole, the molecular formula is C 10 h 17 N 3 S, the relative molecular weight is 211.33. The chemical formula is as follows: [0004] [0005] The commonly used pramipexole salt is pramipexole dihydrochloride monohydrate, the molecular formula is C 10 h 17 N 3 S.2HCl.H 2 O, with a molecular weight of 302.27, is a white to yellowish white, odorless, crystallin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/428A61P25/16
Inventor 白杰郭夏宋雪梅
Owner BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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