Flurarizine dropping pill and preparing method thereof

The technology of flunarizine and dropping pills is applied in the field of flunarizine dropping pills and preparation thereof, which can solve the problems of low dissolution rate and degree of dissolution, influence on flunarizine hydrochloride, long disintegration time, etc. High rate and dissolution, significant pharmacotherapeutic and pharmacoeconomic significance, good compliance

Inactive Publication Date: 2004-04-14
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the flunarizine hydrochloride preparations currently on the market in my country only have capsules, which not only has a single dosage form, but also because flunarizine hydrochloride is very slightly dissolved in water, the disintegration time is long, the dissolution rate and dissolution rate are low, and a large number of auxiliary materials are used. There are obvious defects in children, elderly patients, patients with dysphagia, especially stroke patients and epilepsy patients, such as inconvenient administration and poor compliance, which affect the full play of the clinical therapeutic effect of flunarizine hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0088] Prescription:

[0089] Flunarizine hydrochloride 2.95g (equivalent to flunarizine 2.5g)

[0090] Macrogol 6000 2g

[0091] Macrogol 4000 16g

[0092] Mannitol 1g

[0093] Cysteine ​​Hydrochloride 0.06g

[0094] Makes 1000 capsules

[0095] Preparation method: Take flunarizine hydrochloride, mannitol and cysteine ​​hydrochloride and mix fine powder through superfine grinding through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 and polyethylene glycol 4000 mixed matrix, and mix well , using simethicone oil as a cooling agent, drop into legal pellets, dry, and obtain.

example 2

[0097] prescription:

[0098] Flunarizine hydrochloride 2.95g (equivalent to flunarizine 2.5g)

[0099] Macrogol 6000 2g

[0100] Macrogol 4000 16g

[0101] Mannitol 1g

[0102] Arginine 0.06g

[0103] Makes 1000 capsules

[0104] Preparation method: Take flunarizine hydrochloride, mannitol and arginine and add the mixed fine powder of flunarizine hydrochloride, mannitol and arginine through a 200-mesh sieve into the molten polyethylene glycol 6000 and polyethylene glycol 4000 mixed matrix, mix well, and Simethicone oil is used as a cooling agent, and the pellets are prepared by dropping and drying.

example 3

[0106] prescription:

[0107] Flunarizine hydrochloride 2.95g (equivalent to flunarizine 2.5g)

[0108] Macrogol 6000 2g

[0109] Macrogol 4000 16g

[0110] Cysteine ​​Hydrochloride 0.06g

[0111] Makes 1000 capsules

[0112] Preparation method: Take flunarizine hydrochloride and cysteine ​​hydrochloride and mix fine powder through superfine grinding through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 and polyethylene glycol 4000 mixed matrix, mix well, and Simethicone oil is used as a cooling agent, and the pellets are prepared by dropping and drying.

[0113] 4. Example 4

[0114] prescription:

[0115] Flunarizine hydrochloride 2.95g (equivalent to flunarizine 2.5g)

[0116] Macrogol 6000 2g

[0117] Macrogol 4000 16g

[0118] Lactose 1g

[0119] Leucine 0.06g

[0120] Makes 1000 capsules

[0121] Preparation method: Take flunarizine hydrochloride, lactose and leucine, and add ...

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PUM

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Abstract

The invention is a Flunarizine drop pill and preparing method. It is prepared by micronization and drop-pill producing technique. It can enhance disintegrating and dissolving speed, stripping rate and degree, stability, and largely reduce the dosage of assistant material, convenient to carry and take. It can be sucked and also swallowed, adapted to children, older folks, and difficult-swallowing patients, especially the patients suffering from cranial vascular disease.

Description

technical field [0001] The present invention relates to flunarizine dripping pills and a preparation method thereof, specifically (E)-1-[bis(4-fluorophenyl)methyl]-4-(2-propenyl-3-phenyl The dihydrochloride of )-piperazine or the salt of other forms are the drop pills that active ingredient is made. Background technique [0002] Flunarizine is a selective calcium channel blocker, a selective calcium influx blocker that protects brain cells. It blocks or alleviates other ischemic injuries by antagonizing the intracellular calcium overload of the vestibulo-cochlear nucleus, and achieves brain protection and anti-vertigo effects. It can reduce the volume of cerebral infarction, reduce the degree of brain damage, inhibit the contraction of vascular smooth muscle, dilate blood vessels, increase blood flow in arterioles, and improve microcirculation. [0003] As a selective calcium ion blocker, flunarizine has a clear mechanism of action and curative effect in the treatment of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P9/00A61P9/02A61P9/10A61P17/02A61P25/06A61P25/08
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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