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Application of Huperzine A in preparation of medicines preventing and treating multiple sclerosis disease

A technology of multiple sclerosis and huperzine A, applied in allergic diseases, drug combinations, nervous system diseases, etc., can solve problems such as the efficacy and application of Huperzine A that have not been reported

Inactive Publication Date: 2013-01-02
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Taking a comprehensive view of the research at home and abroad, there is no report on the efficacy and application of Huperzine A in the prevention and treatment of multiple sclerosis.

Method used

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  • Application of Huperzine A in preparation of medicines preventing and treating multiple sclerosis disease
  • Application of Huperzine A in preparation of medicines preventing and treating multiple sclerosis disease
  • Application of Huperzine A in preparation of medicines preventing and treating multiple sclerosis disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Experimental animals:

[0039] A total of 40 SPF-grade female C57BL / 6 mice were used in this experiment, aged 8 weeks, weighing 16-20 g (Experimental Animal Center, Chinese Academy of Sciences). The feeding conditions are clean, 5-6 / cage, with random water supply; during the experiment period, paralyzed and endangered mice above grade 3 were fed in single cages, and the rat food was soaked in feeding water before being fed; the experimental animals were grouped completely randomly.

[0040] 2. EAE model preparation:

[0041] (1) Emulsifier preparation: oligodendrocyte glycoprotein polypeptide fragment-MOG 35-55 (artificially synthesized by Shanghai Huada Tianyuan Company, HPLC grade, purity 95%), complete Freund's Adjuvant (Complete Freund's Adjuvant, CFA, Sigma Company, F5881), BCG (60mg / support, Beijing Institute of Biological Products) fully emulsified Formulated as a white viscous water-in-oil formulation; each mouse requires 0.2ml of emulsifier containing 300u...

Embodiment 2

[0070] 1. Experimental animals:

[0071] A total of 40 SPF-grade female C57BL / 6 mice were used in this experiment, aged 8 weeks, weighing 16-20 g (Experimental Animal Center, Chinese Academy of Sciences). The feeding conditions are clean level, 5-6 birds / cage, free water supply. During the experiment period, the paralyzed and endangered mice above grade 3 were fed in single cages, and the rat food was soaked in feeding water before being fed; the experimental animals were divided into groups by a completely random method.

[0072] 2. EAE model preparation:

[0073] (1) Emulsifier preparation: oligodendrocyte glycoprotein polypeptide fragment-MOG 35-55 (artificially synthesized by Shanghai Huada Tianyuan Company, HPLC grade, purity 95%), complete Freund's Adjuvant (Complete Freund's Adjuvant, CFA, Sigma Company, F5881), BCG (60mg / support, Beijing Institute of Biological Products) fully emulsified Dubbed into a white viscous water-in-oil agent. Each mouse requires 0.2ml of e...

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Abstract

The invention relates to a new medicinal application of Huperzine A, specifically the application in preparation of medicines preventing and treating multiple sclerosis disease, falling into the pharmaceutical field. Huperzine A is a Chinese medicine effective component monomer with the structure of formula (I). The present invention uses whole animal model experiments, and the results show that Huperzine A has significant improvement on the neurological function score of a mouse model with experimental autoimmune encephalomyelitis, and obvious inhibition effect on inflammatory cell infiltration of the central nervous system, and can be used in preparing medicines preventing and treating multiple sclerosis disease.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the new medicinal use of traditional Chinese medicine monomer Huperzine A (Huperzine A), in particular to the use of Huperzine A in preparing medicines for preventing and treating multiple sclerosis. Background technique [0002] The prior art discloses that multiple sclerosis (Multiple Sclerosis, MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system, and its clinical manifestations are relapse-remitting and progressively aggravated neurological dysfunction, Patients have symptoms and signs of varying degrees of limb paralysis, visual impairment, nystagmus, ataxia, and sensory disturbance, which seriously affect work and quality of life. According to statistics, the main onset age of multiple sclerosis is between 20 and 40 years old, and women are higher than men; the prevalence of multiple sclerosis in the world is 30 to 80 patients per ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P37/02A61P25/28A61P29/00A61P25/00
Inventor 汪军吴根诚王彦青
Owner FUDAN UNIV
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