Snakegourd peel injection formulation and preparation method thereof

An injection preparation, the technology of Trichosanthes rind, which is applied in the field of medicine, can solve the problems of unstable content and low yield of Trichosanthes rind extract, and achieve the effects of reducing the process, reducing the incidence of pollution and stabilizing the quality

Inactive Publication Date: 2013-01-09
西藏博睿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield of the Trichosanthes rind extract obtained by the method is low, and the content is unstable

Method used

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  • Snakegourd peel injection formulation and preparation method thereof
  • Snakegourd peel injection formulation and preparation method thereof
  • Snakegourd peel injection formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of Trichosanthes bark extract is:

[0038] (a) Pulverize the Trichosanthes peel into the Trichosanthes peel powder with a particle size of 250 μm;

[0039] (b) Take 100g of the powder in (a) and add 500ml of water to extract for 8 minutes under the condition of 300MPa, release the pressure, collect the filtrate after filtration, and concentrate the filtrate for the first time to a relative density of 1.1 at 50°C and a vacuum of 0.08MPa , to obtain the first extract;

[0040] (c) After taking the first extract and dialysis with a 22mm semi-permeable membrane at 5°C, collect the retained liquid, react with a mixed solution of chloroform-n-butanol with a volume ratio of 4:1 to deproteinize, collect the water layer, and filtrate Concentrate for the second time to a relative density of 1.1 at 50°C with a vacuum of 0.08 MPa to obtain the second extract;

[0041] (d) Take the second extract and add ethanol with a concentration of 95%, let it stand for ...

Embodiment 2

[0043] The preparation method of Trichosanthes bark extract is:

[0044] (a) Pulverizing the Trichosanthes rind into the Trichosanthes rind powder with a particle size of 200 μm;

[0045] (b) Take 100g of the powder in (a) and add 600ml of water to extract it under the condition of 350MPa for 7min, remove the pressure, collect the filtrate after filtration, the filtrate is concentrated at 55°C and the vacuum degree is 0.08MPa for the first time until the relative density is 1.13, obtain the first extract;

[0046] (c) After getting the first medicinal extract at 4.5 DEG C and dialysis with a 22mm semi-permeable membrane, collect the retentate, react with a mixed solution of chloroform and n-butanol with a volume ratio of 4:1 for deproteinization, collect the water layer, and the filtrate in 55°C and a vacuum of 0.08MPa for the second concentration to a relative density of 1.13 to obtain the second extract;

[0047] (d) Take the second extract and add ethanol with a concentra...

Embodiment 3

[0049] The preparation method of Trichosanthes bark extract is:

[0050] (a) Pulverizing the Trichosanthes rind into the Trichosanthes rind powder with a particle size of 150 μm;

[0051] (b) Take 100g of the powder in (a) and add 700ml of water to extract for 6min under the condition of 350MPa, release the pressure, collect the filtrate after filtration, and concentrate the filtrate for the first time to a relative density of 1.2 at 50°C and a vacuum of 0.08MPa , to obtain the first extract;

[0052] (c) After getting the first medicinal extract to be dialyzed with a 22mm semi-permeable membrane at 3°C, collect the retention liquid, react with a mixed solution of chloroform and n-butanol with a volume ratio of 5:1 for deproteinization, collect the water layer, and filtrate in 50°C, the vacuum degree is 0.08MPa and the second concentration is to a relative density of 1.2 to obtain the second extract;

[0053] (d) Take the second extract and add ethanol with a concentration o...

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Abstract

The invention provides a snakegourd peel injection formulation and a preparation method of the snakegourd peel injection formulation, and belongs to the technical field of medicines. A preparation method of a snakegourd peel extract comprises the following steps of: crushing snakegourd peels into snakegourd peel powder with particle diameters being less than and equal to 250 Mum; adding the powder into water, extracting under certain pressure, removing the pressure, filtering, and then concentrating to obtain a first extractum; enabling the first extractum to pass through a semipermeable membrane, collecting retention liquid, reacting with a mixed solution of chloroform and n-butyl alcohol to remove proteins, collecting a water layer, and concentrating to obtain a second extractum; and adding the second extractum into ethanol, standing, centrifuging, taking supernate, concentrating to obtain a third extractum, filtering and then collecting a filtrate. The preparation method is high in working efficiency and low in preparation cost, and the injection formulation prepared from an extracting solution obtained by the method is stable in quality and high in safety.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injection preparation of Trichosanthes quince and a preparation method thereof. Background technique [0002] Gualou is a commonly used traditional Chinese medicine, and it is an important medicine for treating chest pain in traditional Chinese medicine. The 1995 edition of the Chinese Pharmacopoeia stipulates that Trichosanthes is the dried mature fruit of Trichosanthes kirilowii Maxim. or T. rosthornii Harms of Cucurbitaceae (Cucurbitaceae), and the dry seeds of the fruit parts of the two plants are also stipulated. and dried mature peel are commonly used traditional Chinese medicine Trichosanthes seeds and Trichosanthes peel respectively. Gualou, Gualou seeds, and Gualou skin have different clinical applications because of the different parts to be used. Gualou skin focuses on clearing heat-phlegm, benefiting qi and broadening the chest, and is used for phleg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/428A61K9/08A61P9/10A61P11/00A61K131/00
Inventor 曹捷高帆周战尚磊
Owner 西藏博睿生物科技有限公司
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