Traditional Chinese medicine compound preparation for treating non-small cell lung cancer and preparation method thereof

A technology of non-small cell lung cancer and compound preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc. It can solve the problems of not meeting market demand, low preservation, difficult quality control, etc., and achieve synergy Attenuation effect, significant effect of curative effect

Inactive Publication Date: 2013-01-09
天津中医药大学第一附属医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional dosage form of Xiaoyan Decoction is water decoction. Its quality is difficult to control and its preservation is low. Patients need to decoct and take a large amount of water decoction according to the doctor's advice. The dosage is large, especially for cancer patients who are weak and take too much medicine. Inconvenience, poor taste when taking, which limits its application and does not meet market demand
In order to give full play to the clinical curative effect of the medicine of the present invention and control its internal quality, we have carried out in-depth research on this prescription, and there is no such variety on the market at present.

Method used

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  • Traditional Chinese medicine compound preparation for treating non-small cell lung cancer and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating non-small cell lung cancer and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating non-small cell lung cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] The raw materials were weighed according to the following proportions: 6 parts of astragalus, 3 parts of heterophylla, 3 parts of turmeric, 3 parts of turmeric, 6 parts of raw oyster, 3 parts of hive, 2 parts of Prunella vulgaris, and 3 parts of Hedyotis diffusa.

[0118] (1) Take turmeric, turmeric, Hedyotis diffusa, Prunella vulgaris, add 12 times the amount of 85% ethanol to extract 3 times, each time for 2 hours, extract the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract, spare;

[0119] (2) Take raw oysters and hives and fry them for half an hour, then add astragalus and heterophylla, add 10 times the amount of water, heat and extract twice, 1.5 hours each time, combine the water extracts, filter, concentrate, dry, grind, Get the extract and reserve;

[0120] (3) Pass the above-mentioned dry powder extract through an 80-mesh sieve, add an appropriate amount of powdered sugar, granulate, and pack to obtain the pharmaceutical granu...

Embodiment 2

[0122] The raw materials were weighed according to the following proportions: 8 parts of astragalus, 5 parts of heterophylla, 4 parts of turmeric, 4 parts of turmeric, 5 parts of raw oyster, 4 parts of hive, 3 parts of Prunella vulgaris, and 5 parts of Hedyotis diffusa. Steps (1) and (2) are the same as in Example 1, (3) Add appropriate amount of sucrose and dextrin to the extracts in (1) and (1), mix well, make granules, dry, and spray the obtained in (1) Grass nuts, and then prepare capsules according to conventional technology.

Embodiment 3

[0124] The raw materials were weighed according to the following proportions: 10 parts of astragalus, 6 parts of heterophylla, 8 parts of turmeric, 8 parts of turmeric, 6 parts of raw oyster, 5 parts of hive, 4 parts of Prunella vulgaris, and 6 parts of Hedyotis diffusa.

[0125](1) Get turmeric, turmeric, Hedyotis diffusa, Prunella vulgaris, add 15 times the amount of 50% ethanol to extract 4 times, each time for 1.5 hours, extract the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract, spare;

[0126] (2) Take raw oysters and hives and fry them for half an hour, then add astragalus and heterophylla, add 25 times the amount of water, heat and extract once, 3 hours each time, combine the water extracts, filter, concentrate, dry, and pulverize, Get the extract and reserve;

[0127] (3) Combine the above-mentioned extracts, mix them evenly, add an appropriate amount of auxiliary materials, make granules, dry, and compress into tablets to obtain ph...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating a non-small cell lung cancer and a preparation method of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation is prepared from radix astragali, radix pseudostellariae, rhizoma curcumae longae, radix curcumae, raw oyster shell, apiary, spica prunellae and spreading hedyotis herb as raw materials. The traditional Chinese medicine compound preparation is prepared into a medicinal dosage form, which comprises the steps of extracting rhizoma curcumae longae, radix curcumae, spreading hedyotis herb and spica prunellae with ethanol, and decompressing, concentrating and drying an extracting solution to obtain an extract; decocting the rest of medicines with water, and concentrating and drying the extracting solution to obtain an extract; and mixing the dried extracts to obtain the medicinal dosage form. The extracts provided by the invention have the effects of strengthening healthy energy and removing stasis and eliminating mass and eliminating stagnation, and are utilized to treat qi deficiency and toxic stasis type non-small cell lung cancer. The compound preparation of the extracts has the characteristics of being convenient to carry and take, high in bioavailability and good in controllability and stability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine compound preparation for treating non-small cell lung cancer and a preparation method thereof. Background technique [0002] Lung cancer is currently the malignant tumor with the highest morbidity and mortality in the world, and there are about 1 million new lung cancer patients worldwide every year. In the past 20 years, the incidence of lung cancer in my country has been increasing at an annual rate of 11%. It is estimated that by 2020, there will be 500,000 new lung cancer cases in my country every year, and China will become the world's largest lung cancer country. Non-small cell lung cancer (NSCLC) accounts for about 80% of the lung cancer population, and about 70% of patients are diagnosed at advanced stage (stage III, stage IV), and the death-to-occurrence ratio is as high as 90%. Among them, stage IIIB and stage IV The 5-year su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/56A61K35/64A61K35/618
Inventor 贾英杰张铁军陈军田成旺孙一予朱雪瑜
Owner 天津中医药大学第一附属医院
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