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Application of Houttuynoid C in anti-tubercle bacillus medicine

A technology of anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effect of highlighting substantive features, broad application prospects, and expanding types

Inactive Publication Date: 2013-01-16
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of Houttuynoid C in anti-tubercle bacillus medicine
  • Application of Houttuynoid C in anti-tubercle bacillus medicine
  • Application of Houttuynoid C in anti-tubercle bacillus medicine

Examples

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Embodiment 1

[0016] Embodiment 1: the preparation of compound Houttuynoid C tablet involved in the present invention:

[0017] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0018] Embodiment 2: the preparation of compound Houttuynoid C capsule of the present invention:

[0019] Get 20 grams of compound Houttuynoid C, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1 Determination of the absolute concentration of Houttuynoid C anti-BCG (BCG) by solid medium dilution method

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] Make Houttuynoid C into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Houttuynoid C to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50~55°C), mixed evenly to make Houttuynoid C, the concentrations are 6.0 ug / ml, 4.0 ug / ml, 3.0 ug / ml, 2.0...

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Abstract

The invention discloses application of Houttuynoid C in preparing an anti-tubercle bacillus medicine. Aiming at the current situation that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of tuberculosis and the appearance of multi-drug resistant strain of mycobacterium tuberculosis at present, the invention discovers that Houttuynoid C has obvious activity in suppressing tubercle bacillus and has good application prospects. The application of Houttuynoid C in preparing an anti-tubercle bacillus medicine is disclosed for the first time; and since the skeleton type is a brand new one and the activity in suppressing tubercle bacillus is unexpectedly strong, the possibility of any other compound offering any inspiration does not exist, outstanding substantial characteristics are obtained, and an obvious progress is made in preventing and treating tubercle bacillus infection.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Houttuynoid C in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/06
Inventor 俞骁施桦吴俊华
Owner 吴俊华
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