Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Houttuynoid D in tubercle bacillus resistant medicament

A technology of anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effects of expanding types, strong inhibitory activity of tuberculosis, and highlighting substantive characteristics

Inactive Publication Date: 2013-01-16
JIANGSU KANGHENG CHEM
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Contents of the invention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Houttuynoid D in tubercle bacillus resistant medicament
  • Application of Houttuynoid D in tubercle bacillus resistant medicament
  • Application of Houttuynoid D in tubercle bacillus resistant medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of compound Houttuynoid D tablet involved in the present invention:

[0018] Take 20 grams of compound Houttuynoid D, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0019] Embodiment 2: the preparation of the compound Houttuynoid D capsule involved in the present invention:

[0020] Take 20 grams of compound Houttuynoid D, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0021] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0022] Experimental example 1 Determination of absolute concentration of Houttuynoid D anti-BCG (BCG) by solid medium dilution method

[0023] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0024] Make Houttuynoid D into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Houttuynoid D to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50~55°C), mixed evenly, and made to contain Houttuynoid D, the concentrations are 6.0 ug / ml, 4.0 ug / ml, 3.0 u...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of Houttuynoid D in preparation of a tubercle bacillus resistant medicament. According to the current situation that the incidence and the mortality of tuberculosis rise due to high incidence of the conventional tuberculosis and appearance of multi-resistant strains of tubercle bacilli, the Houttuynoid D has the activity of remarkably inhibiting the tubercle bacilli and has a good application prospect. The invention discloses the application of the Houttuynoid D in preparation of the tubercle bacillus resistant medicament for the first time, the skeleton type belongs to a brand-new skeleton type, the Houttuynoid D has unexpected strong inhibiting activity on the tubercle bacilli, the probability of giving any revelation by other compounds does not exist, and the Houttuynoid D has predominant substantial characteristics and obviously makes a remarkable progress on prevention and treatment of tubercle bacillus infection.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Houttuynoid D in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/06
Inventor 吴俊艺冯怡吴俊华
Owner JIANGSU KANGHENG CHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com