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Extraction method of corn stigma total flavonoids

An extraction method, the technology of the cob hair, which is applied in the field of separation and purification of natural products, can solve the problems of the total flavonoids of the cob hair, the large amount of solvent used, and the long extraction time, etc., so as to improve economic and social benefits, and use less solvent , good reproducibility

Inactive Publication Date: 2013-02-06
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few methods for extracting flavonoids from the bark, and most of them are prepared in small quantities in the laboratory (Tong Wanhong et al., China Traditional Chinese Medicine Information, 2010, 5, 2(9): 146-148), which has the disadvantages of long extraction time and the use of solvents. Large quantity and other disadvantages, there is no relevant patent on the extraction method of total flavonoids from bark hair in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The dried stick hair is crushed, 2kg is taken, put into the extraction tank, and ethanol is used as a carrier, the amount of the carrier is 25% of the amount of the extracted material, the temperature of the extraction kettle is set to 40°C, the temperature of the analysis kettle is 38°C, and the extraction kettle is The pressure is 28MPa, CO 2 The flow rate is 30L / h. After 2 hours of extraction, the extract is decomposed. The pressure of the desorption tank is 6MPa. The extract is put into a Soxhlet reflux device, and petroleum ether is added to decolorize at 60°C, and then freeze-dried to obtain 61g of total flavonoids from the bark.

Embodiment 2

[0014] Grind the dry stick hair, take 2kg, put it into an extraction tank, and use ethanol as a carrier, the amount of the carrier is 30% of the amount of the extracted material, set the temperature of the extraction kettle to 38°C, and the temperature of the analysis kettle to be 35°C. The pressure is 30MPa, CO 2 The flow rate is 25L / h. After 2.5 hours of extraction, the extract is analyzed. The pressure of the analysis kettle is 6.5MPa. The extract is put into a Soxhlet reflux device, and petroleum ether is added to decolorize at 60°C, and freeze-dried to obtain 53g of the total flavonoids of bark hair. .

Embodiment 3

[0016] Grind the dry stick hair, take 2kg, put it into the extraction tank, and use ethanol as a carrier, the amount of the carrier is 25% of the amount of the extracted material, set the temperature of the extraction kettle to 35°C, and the temperature of the analysis kettle to be 30°C. The pressure is 32MPa, CO 2 The flow rate is 35L / h. After 3 hours of extraction, the extract is decomposed. The pressure of the desorption tank is 6MPa. The extract is put into a Soxhlet reflux device, and petroleum ether is added to decolorize at 60°C, and then freeze-dried to obtain 58g of total flavonoids from the bark.

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PUM

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Abstract

The invention discloses an extraction method of corn stigma total flavonoids. The invention belongs to extraction methods of total flavonoids. According to the invention, dry corn stigma is crushed into powder; a supercritical CO2 fluid extraction method is adopted, and ethanol is adopted as a carrying agent; an obtained extract is subjected to reflux decolorization by using petroleum ether; and an obtained material is lyophilized, such that a corn stigma total flavonoid product is obtained. The method provided by the invention is simple, fast, and non-toxic. The method is a green production method.

Description

technical field [0001] The invention belongs to the field of separation and purification of natural products, and relates to an extraction process of effective substances in natural products, in particular to a method for extracting total flavonoids from bark hair. Background technique [0002] Cob hair is the style and stigma of plants of the genus Zea in Poaceae. Cob hair contains a variety of chemical components, mainly flavonoids and their glycosides, sterols, alkaloids, sugars, organic acids and volatile oils. It is sweet, light, and flat in nature. It has diuretic, anti-tumor, anti-allergic, anti-aging, hypoglycemic, and hypotensive effects. It is used to treat hypertension, diabetes and other diseases. There are very rich resources of stick hair, but only a small amount is used as medicine at present, and most of them are discarded. [0003] At present, there are few methods for extracting flavonoids from the bark, and most of them are prepared in a small amount in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/10A61P9/12A61K133/00
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司