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New application of patchoulic alcohol

A technology of patchouli alcohol and usage, applied in the direction of active ingredients of hydroxyl compounds, antiviral agents, etc., to achieve the effect of low toxicity and side effects

Inactive Publication Date: 2013-02-13
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the 1990s, researchers have discovered many new antiviral drugs. At present, there are more than 20 antiviral drugs in clinical use, but their exact efficacy is still controversial.
[0007] At present, there are no related reports on the use of patchouli alcohol to resist Coxsackie virus and treat Coxsackie virus infectious diseases

Method used

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  • New application of patchoulic alcohol
  • New application of patchoulic alcohol
  • New application of patchoulic alcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Anti-Coxsackie virus effect of patchouli alcohol

[0020] 1. Materials and instruments

[0021] 1.1 Cell strains and virus strains

[0022] 1.1.1 Cell lines:

[0023] Hela cells (cervical cancer cells) were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0024] 1.1.2 Virus strains:

[0025] Coxsackievirus group B type 3 (hereinafter referred to as CVB-3) was derived from a clinical isolate provided by the Sichuan Clinical Inspection Center.

[0026] 1.2 Drugs and control drugs

[0027] Test drug: patchouli alcohol.

[0028] Positive drug: ribavirin injection: the specification is 100 mg / ml, produced by Tianjin Pharmaceutical Jiaozuo Co., Ltd.

[0029] Approval number: Guoyao Zhunzi H19992467, production batch number: 10110521;

[0030] 1.3 Media, reagents and consumables

[0031] RPMI-1640 medium (Gibco TM company, batch number 1313945); fetal bovine serum (HyClone Biochemical Products (Beijing) Co....

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Abstract

The invention discloses an application of patchoulic alcohol in the preparation of drugs against coxsackie virus. The patchoulic alcohol can effectively restrain synthesis of coxsackie virus B type 3, has a certain function against the coxsackie virus, and can be used in the treatment of coxsackie virus infectious diseases, especially coxsackie virus B type 3 infectious diseases; and simultaneously, the patchoulic alcohol is far less poisonous to host cells compared with positive drug ribavirin, and lower in toxic and side effects, thus providing a safe and effective new choice for clinical medication.

Description

technical field [0001] The present invention relates to the new application of patchouli alcohol. Background technique [0002] Coxsackie virus (Coxsaekieviurs), belonging to Picomaviridea and Enterovirus, can be divided into Group A and Group B according to their pathogenicity to suckling mice. This type of virus has no envelope, positive strand RNA, and a virus with a positive 20-hedron protein shell. Its gene body has a protein at the 5' end that is used as a prime for RNA replication. Among them, Coxsackievirus group B (CVB) can cause epidemic chest pain, aseptic encephalitis, meningoencephalitis and pericarditis, especially CVB3 is the main pathogen of viral myocarditis, which can cause focal necrosis of myocardial tissue , accompanied by pathological changes such as inflammatory cell infiltration and cardiomyocyte lysis, persistent virus infection can lead to dilated cardiomyopathy, which poses a great threat to humans. [0003] Since the 1990s, researchers have disc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P31/14
Inventor 彭成魏晓露熊亮万峰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE