Formation method of drug coating and drug coating prepared by same
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A technology of drug coating and drug molecules, applied in the field of medicine, can solve problems such as narrow space
Active Publication Date: 2013-03-27
PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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Moreover, the space in the nasal cavity is narrow, and even non-irritating solvents cannot volatilize smoothly, leaving only effective drugs and contro...
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Embodiment 1
[0051] Example 1 Solid particle mixture according to one embodiment of the present invention
no. 1 approach
[0052] According to the first embodiment of the present invention, the drug coating formed by the mixture of solid particles can be formed by physical cross-linking of a single solid particle in a wet state. At this time, the "single solid particle" refers to a solid particle with the same form of expression. In this embodiment, the solid particle is a uniformly dispersed particle 2, such as figure 2 shown.
[0053] Usually, the solid particles at least include drug molecules and polymers, and the polymers can be a degradable hydrophilic / water-soluble polymer, or a combination of degradable polymers and hydrophilic / water-soluble polymers. mixture. Wherein, the drug molecules are uniformly dispersed in the polymer. For example in figure 2 and image 3 In , the number 21 indicates the degradable polymer, the number 22 indicates the hydrophilic / water-soluble polymer, and the number 23 indicates the drug molecule.
[0054] The method of forming the microparticles in uniform...
Embodiment 2
[0067] Example 2 Solid particle mixture according to another embodiment of the present invention
[0068] According to the second embodiment of the present invention, the drug coating formed by the mixture of solid particles can be formed by physical cross-linking of a single solid particle in a wet state. At this time, the "single solid particle" refers to a solid particle with the same form of expression. In this embodiment, the solid particle is a particle 3 in the form of a skin-core, such as Figure 7 shown.
[0069] Usually, the solid particles at least include drug molecules and polymers, and the polymers can be a degradable hydrophilic / water-soluble polymer, or a combination of degradable polymers and hydrophilic / water-soluble polymers. mixture. Wherein, the drug molecules are uniformly dispersed in the polymer. For example in Figure 7 In , the number 31 represents a degradable polymer, the number 32 represents a hydrophilic / water-soluble polymer, and the number...
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Abstract
The invention provides a formation method of a drug coating. The formation method comprises the following steps in sequence: providing at least one dried solid particle, wherein the dried solid particle comprises polymers and drug molecules; spraying a dried solid particle mixture formed by the dried solid particles on a moist surface, wherein the polymers are swelled on the moist surface, so that the physical crosslinking can be carried out between the solid particles so as to form the drug coating; or spraying the dried solid particle mixture formed by the dried solid particles on a dried surface, and then spraying atomized water drops on the surface of the dried solid particle mixture, wherein the polymers are swelled to result in physical crosslinking between the solid particles so as to form the drug coating. The drug coasting provided by the invention has the advantages that the slow release time can be controlled to reach 1 to 90 days, and preferably 3 to 30 days, so that the drug coating can be kept on the surface of a lesion part for a long time in order to come into play for a long time, and as a result, the nasal diseases such as nasosinusitis and allergic rhinitis can be treated better.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a method for forming a drug coating and the drug coating. Background technique [0002] Sinusitis and allergic rhinitis are common and frequently-occurring diseases of ENT, which occur between the ages of 5 and 79. According to the survey by the health department: the current global incidence of allergic rhinitis is as high as 10% to 14%, and the incidence of sinusitis accounts for about 15% of the population. Nearly 600 million people in the world are suffering from rhinitis, and it is gradually Upward trend. [0003] 66% of asthma patients are victims of allergic rhinitis. According to experts, if allergic rhinitis is not properly treated, more than one-third of patients will eventually develop asthma. [0004] Nasal sinuses, also known as paranasal sinuses and paranasal sinuses, are multiple air-containing bony cavities around the nasal cavity, which communicate with the nasal cavit...
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