Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of agomelatine solid preparation

A solid preparation and carrier technology, which is applied in the field of medicine, can solve the problems of reducing production efficiency and cumbersome production, and achieve the effects of simple method, saving cost and production time, and good in vitro dissolution performance

Active Publication Date: 2013-03-27
ZHEJIANG HUAHAI PHARMA CO LTD
View PDF5 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the micronization of drugs requires special airflow pulverization equipment, which is cumbersome in production and requires quality control of drug particle size, which reduces production efficiency.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of agomelatine solid preparation
  • Preparation method of agomelatine solid preparation
  • Preparation method of agomelatine solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of the composition of agomelatine:

[0024] Weigh 10 g of crystal form II agomelatine and 20 g of crospovidone (model Kollidon CL) and mix them evenly, then add them to an oven at 160° C. for 10 minutes, take them out and pass through a sieve to cool.

Embodiment 2

[0026] Preparation of the composition of agomelatine:

[0027] Weigh 100 g of agomelatine of crystal form VI and 300 g of crospovidone (model Kollidon CL-M) and add them to a jacketed granulator for granulation. The temperature is set at 105° C. and stirred for 5 minutes. Take out and sieve to cool.

Embodiment 3

[0029] Preparation of the composition of agomelatine:

[0030] Weigh 10 g of crystal form II agomelatine and 40 g of crospovidone (Polyplasdone XL) and mix them evenly, then add them to an oven at 140° C. for 10 minutes, take them out and pass through a sieve to cool.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of an agomelatine solid preparation. The preparation method comprises the steps of mixing agomelatine or pharmaceutically acceptable salts with polyvinylpolypyrrolidone; hot-melting the mixture to prepare particles; and mixing the particles with other pharmaceutically acceptable carriers to be tabletted or filled to form capsules. The agomelatine solid preparation prepared by the method is stable and controllable in quality and high in dissolution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of agomelatine solid preparation. Background technique [0002] Agomelatine tablets (agomelatine tablets) were developed by the French company Servier, the specification is 25mg, and its trade name is Weixin, and the trade name is It is mainly used for the treatment of adult depression. It was approved for marketing by the European Union in February 2009. It is the world's first melatonin receptor agonist antidepressant. Its molecular structural formula is as follows: [0003] [0004] Agomelatine is almost insoluble in hydrochloric acid solution at pH 2.0, acetate buffer at pH 4.5, phosphate buffer at pH 6.8 and water, so it is necessary to improve its dissolution rate in the preparation process to enhance its biological properties. Utilization. [0005] Drugs with poor solubility have brought technical difficulties in the development of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K9/16A61K31/165A61K47/32A61P25/24
CPCA61K9/1635A61K9/48A61K9/20A61K9/16A61K9/2027A61K47/32A61K31/165A61P25/24
Inventor 彭俊清徐彪曹宇陈梁杨专余慧李艳艳
Owner ZHEJIANG HUAHAI PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com