Supercharge Your Innovation With Domain-Expert AI Agents!

Application of bafilomycin A1

A technology of bafilomycin and B lymphocytes, applied in the biological field, can solve the problems of expensive treatment costs, achieve the effect of reducing treatment costs and improving the cure rate

Inactive Publication Date: 2013-04-24
SUZHOU UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To solve the problem of high cost of treatment, the fundamental way out is to study alternative drugs or treatment strategies with low prices

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of bafilomycin A1
  • Application of bafilomycin A1
  • Application of bafilomycin A1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0021] The application of bafilomycin A1, the chemical formula of said bafilomycin A1 is C 35 h 58 o 9 , the structural formula of the bafilomycin is .

[0022] Further, the bafilomycin A1 is applied to the preparation of a drug for treating childhood B lymphocytic leukemia.

[0023] Further, the bafilomycin A1 can be used as a targeted therapeutic drug for acute B lymphocytic leukemia.

[0024] Referring to Figure 2, bafilomycin A1 in the range of 0.25-10 nM can effectively inhibit the growth and proliferation of acute lymphoid leukemia cell lines 697, Raji and JurKat cells, and induce ALL through a Caspase-3-independent pathway Apoptosis, no obvious effect on normal lymphocytes and non-cancer cells.

[0025]Referring to Figure 3, in animal experiments, BAF can also effectively reduce the death rate and leukemia progression o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of bafilomycin A1. The chemical formula of the bafilomycin A1 is C35H58O9; and the bafilomycin A1 is applied to the preparation of medicines for treating children acute B lymphocytic leukemia. Research reveals the novel effect of the bafilomycin A1 specificity in killing children acute B-ALL lymphocytic leukemia cancer cells, a new prescription for preparing new medicines for treating leukemia is provided, and meanwhile the bafilomycin A1 plays an important role in reducing the treating cost of children B-ALL and improving the cure rate.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of bafilomycin A1. Background technique [0002] B-cell acute lymphoblastic leukemia (B-ALL) refers to a malignant disease caused by abnormal clonal proliferation of precursor or mature B lymphocytes, and is the first among childhood tumors. In the past 30 years, with the continuous improvement of therapeutic drugs, strategies and methods, the treatment effect of B-ALL in children has been continuously improved. At present, the complete remission (CR) rate of newly diagnosed children with B-ALL has reached over 90%, and the five-year disease-free survival rate has also exceeded 80%. However, in clinical treatment, there are still many children whose condition cannot be controlled, and about 20% of cases in remission children still relapse and lead to death. Compared with my country's Ruijin Hospital in Shanghai, which has made breakthroughs in the treatment of acut...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7048A61P35/00
Inventor 王建荣牛玉娜张素萍袁娜
Owner SUZHOU UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com