Application of salvianolic acid b in the preparation of anti-h5n1 influenza virus medicine

A technology of influenza virus and salvianolic acid, applied in the field of pharmacy, can solve the problems that there is no application of prevention or treatment of H5N1 influenza virus

Inactive Publication Date: 2016-12-14
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although salvianolic acid B and its derivatives have strong pharmacological effects in anti-oxidation, anti-liver damage, anti-tumor, anti-depression, anti-aging and anti-thrombosis, there is no application in the prevention or treatment of H5N1 influenza virus

Method used

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  • Application of salvianolic acid b in the preparation of anti-h5n1 influenza virus medicine
  • Application of salvianolic acid b in the preparation of anti-h5n1 influenza virus medicine
  • Application of salvianolic acid b in the preparation of anti-h5n1 influenza virus medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 Salvianolic acid B is to H5N1 type influenza virus RNA polymerase subunit PA N Determination of protein inhibitory activity

[0034] Dissolve 5.00 mg of salvianolic acid B (purchased from Chengdu Master Reference Substance Co., Ltd., HPLC analysis content > 98%) in 100.00 μL of 95% DMSO in double distilled water, and prepare a standard concentration of 50.00 mg / mL solution.

[0035] Take 10.00 μL of salvianolic acid B standard solution and carry out 2-fold increasing gradient dilution with 95% DMSO, and co-dilute into different concentration test solutions as shown in Table 2. Adopt the enzymatic activity test method as described in the pharmacological experiment part to measure the enzymatic activity curve of the solution to be tested, and calculate the PA N The remaining activity of the protein was repeated 3 times in parallel. The results of the remaining activity determined are shown in Table 2.

[0036] Divide the diluted compound concentration by ...

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Abstract

The present invention provides the application of salvianolic acid B in the preparation of medicines for preventing or treating H5N1 influenza virus, wherein the salvianolic acid B has the following structural formula: salvianolic acid B can effectively inhibit the RNA polymerase subunit of H5N1 influenza virus Activity of PAN protein.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of salvianolic acid B. Background technique [0002] Influenza is a kind of epidemic disease with strong transmissibility, pathogenicity and variability, and spreads to a wide range. It is caused by infection of different subtypes of virus strains and is mainly divided into three categories: A, B and C. Especially type A. Influenza A virus RNA polymerase PA subunit N-terminal protein (PA N ) plays a key role in stabilizing PA structure, endonuclease activity, cap structure binding, promoter binding and other functions, and because of its high degree of conservation in the RNA sequences of A, B, and C strains, At present, it has become an important target for the development of broad-spectrum influenza virus inhibitors. Among them, the highly pathogenic avian influenza virus H5N1 subtype belongs to type A influenza virus. Although H5N1 will not be directly transmitted fr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P31/16
Inventor 饶子和杨诚郭宇周红刚陈卫强刘超冯金磊王丽君李金楠
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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