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Application of Aphanamixoid A to rhinitis treatment medicine

A drug and rhinitis technology, applied in the application field of Aphanamixoid A in the treatment of rhinitis drugs, can solve the problems of ineffectiveness and poor efficacy of rhinitis, and achieve the effect of highlighting substantive characteristics and strong activity in treating rhinitis

Inactive Publication Date: 2013-06-05
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of Aphanamixoid A to rhinitis treatment medicine
  • Application of Aphanamixoid A to rhinitis treatment medicine
  • Application of Aphanamixoid A to rhinitis treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:

[0013] Take 20 grams of compound Aphanamixoid A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:

[0015] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Aphanamixoid A of the present invention on ovalbumin-induced allergic rhinitis in rats

[0018] Male SD rats, weighing 180-220 g, were intraperitoneally injected with 1 mg of ovalbumin and 10 mg of aluminum hydroxide gel, and then injected once every other day, a total of 7 times. From the 14th day, 10ul of 1mg / ml ovalbumin physiological saline solution was instilled into the nasal cavities of both sides of the rat every day, 7 times in total. Immediately after the last infusion, observe the number of times the rats sneeze and wipe their noses within 30 minutes, and the test drug is orally administered 1 hour before the last infusion of ovalbumin.

[0019] It can be seen from Table 1 that Aphanamixoid A (10, 20 mg / kg) significantly inhibited the sneezing and scratching nasal reactions in rats with allergic rhinitis induced by ovalbumin. Terfenadine 10mg / kg also showed a significant inhibitory effect.

[0020] Table 1 Effect of ...

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PUM

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Abstract

Aphanamixoid A for treating immunity inflammation is used for preparing immunity inflammation treatment medicine and particularly suitable for preparing rhinitis treatment medicine. Compared with terfenadine and diclofenac sodium, the Aphanamixoid A is obvious in curative effect. The application of the Aphanamixoid A to preparation of the rhinitis treatment medicine is made public for the first time. The skeleton type is fully novel, activity of the Aphanamixoid A in treating rhinitis is surprisingly strong, the possibility that inspiration is obtained from other compounds does not exist, and therefore the Aphanamixoid A has prominent substantive features, and meanwhile, significant progress of the application of the Aphanamixoid A to prevention and treatment of the rhinitis is obviously achieved.

Description

technical field [0001] The invention relates to the application of Aphanamixoid A in preparing medicine for treating rhinitis. Background technique [0002] Rhinitis is a common and frequently-occurring disease in clinical practice. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis, and these drugs have poor or ineffective effects on chronicity and recurrent rhinitis. Therefore, small molecular compounds with clear components, quality control, safety and high efficiency have potential value in the development of drugs for rhinitis treatment. [0003] The compound Aphanamixoid A involved in the present invention was published in 2012 (Cai, J. Y. et al., 2012. Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P11/02
Inventor 黄蓉冯怡龚霞吴俊华
Owner 吴俊华
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