Preparation method of calcium phosphate

Abstract

The invention provides a preparation of calcium phosphate, relates to calcium phosphate, and provides a preparation method of calcium phosphate, which has the advantages that production is continuous and high in yield stable, required raw materials are simple, reaction conditions are mild and controllable, production cycle is short and product quality is uniform and stable. The method comprises the following steps of: 1) preparing raw materials; 2) delivering clear liquid of phase A and clear liquid of phase B prepared in the step 1) to a microchannel continuous mixing system through a metering pump of a raw material delivery system so that liquid components of each phase are uniformly differentiated, and performing a continuous integral reaction to form a calcium phosphate aggregate; 3) delivering the calcium phosphate aggregate obtained in the step 2) to a heating system; 4) feeding into an insulating system; 5) feeding into a cooling system; and 6) delivering the cooled reaction product to a dehydration cleaning device, and drying the cleaned product to obtain calcium phosphate nano-particle powder.

Description

technical field [0001] The invention relates to calcium phosphate, in particular to a method for preparing calcium phosphate based on differential reaction technology. Background technique [0002] Calcium phosphate is widely used in the field of biomedical bone tissue repair because of its better biocompatibility, bioactivity, osteoinductivity and biodegradability. The latest applications also include adsorption of heavy metals in water treatment, drug release, cosmetic repair, cosmetic additives and toothpaste additives. [0003] Chinese patent 200310105951.7 uses calcium nitrate, diammonium hydrogen phosphate and urea as raw materials, uses a multi-frequency sonochemical generator to carry out sonochemical synthesis, filters the suspension, washes, and vacuum-dries to obtain nano-hydroxyapatite powder, and the obtained Hydroxyapatite powder has small particle size, uniform particle size, and no agglomeration. Because the synthesis temperature (40-80°C) is relatively low,...

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Problems solved by technology

[0004] Chinese patent 200610055171.X uses the water-soluble polymer compound polyvinylpyrrolidone (PVP) as a template, and uses calcium nitrate and ammonium phosphate as raw materials. It is left to stand at 25°C for 7 days at room temperature, and the resulting precipitate is washed, suction-filtered, Spherical hydroxyapatite nanocrystalline products can be obtained by drying. This method requires long-term aging, long production cycle, and cumbersome procedures, which is not conducive to the realization of continuous chemical industry mass production.

[0005] Chinese patent 03142004.4 and the journal paper "Journal of Inorganic Materials", 2004, 19 (01): 234-238. all report a kind of preparation method of amorphous nano-calcium phosphate, the synthesis temperature of this kind of method is lower range is 0~20 °C, which limits its synthetic application at room temperature or higher temperature, the energy consumption for cooling is high, and the synthesis cycle is long

[0006] Chinese patent 201110263963.7 discloses a synthesis method of amorphous calcium phosphate, which is synthesized in an ultrasonic environment at 0°C, so it cannot be synthesized at room temperature

In addition, special ultrasonic equipment needs to be added, and the synthesis time is long, which is not conducive to mass production

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