163results about How to "Synthetic strong" patented technology

The present invention relates to one group of Tenofovir monoester compounds and their alkali / acid composites, synthesis process and antiviral application. Extracorporeal experiment shows that the compounds of the present invention have HIV-1 virus copy and HBV virus copy inhibiting activity. The present invention lays foundation for the research and development of the compounds in antiviral application.

The invention provides a microRNA quantitative detection analytic method by utilizing isothermal amplification to synthesize a fluorescent nano silver cluster probe. The method is as below: a DNA amplification template containing three kinds of functional sequences is designed: a sequence binding with a target microRNA, a nicking endonuclease enzyme sequence and a DNA complementary sequence for synthesis of fluorescent nano cluster; when the target microRNA and the DNA amplification template are combined, isothermal amplification reaction and specific enzyme reaction of nicking endonuclease are induced to obtain a large number of single-stranded DNA products; the DNA sequence for synthesis of fluorescent nano silver cluster and a silver nitrate solution are employed to prepare the fluorescent nano silver cluster probe under the reduction of sodium borohydride; fluorescence signal of the reaction system are determined, and a fluorescence change value is calculated; the value is compared with a standard working curve to calculate the concentration of the target microRNA. The method has the advantages of high sensitivity, strong specificity, wide linear detection range, low background signal and simple operation, and can be widely applied to microRNA detection of biological samples such as tissue, blood or cells.

The present invention provides an electrolytic anode for use in electrolytically synthesizing a fluorine-containing substance by using an electrolytic bath containing a fluoride ion including: an electroconductive substrate having a sure including an electroconductive carbonaceous material; and an electroconductive carbonaceous film having a diamond structure, the electroconductive carbonaceous film coating a part of the electroconductive carbonaceous substrate, and a method for electrolytically synthesizing a fluorine-containing substance using the electrolytic anode.

The invention discloses a polyacrylate emulsion and a preparation method thereof. The polyacrylate emulsion is prepared from the following raw materials in parts by weight: 21.1-35.3 parts of a pre-emulsion in a nuclear layer, 21.3-34.1 parts of a pre-emulsion in a crosslinking layer, 8.05-12.2 parts of a pre-emulsion in a shell, 22.21-34.43 parts of initiator aqueous liquor, 0.01-0.08 part of an anionic emulsifier d, 0.04-0.32 part of a non-ionic emulsifier d and 20 parts of deionized water d. The solid content of the target emulsion product disclosed by the invention is over 45%, the storage stability of the emulsion through freeze-thaw stability test is longer than 6 months, and the coating is good in temperature resistance. The emulsion is non-sticky at 200 DEG C, and the adhesive force of the coating to a PVC (polyvinyl chloride) substrate reaches level 1, so that the problems that PVC wallpaper is sticky at high temperature, easy in separation of a plasticizer and intolerant to wiping by organic solvents such as alcohol and the like can be effectively solved.

The invention discloses a green phase bright yellow inorganic nanometer pigment and a preparation method thereof. According to the present invention, by combing a complexation method and uniform precipitation, a small amount of metal ions are used to dope and Bi and V in BiVO4 are simultaneously substituted to prepare a yellow pigment so as to easily inhibit the conversion of the crystal phase structure of the pigment into the tetragonal phase and obtain the pure the monoclinic scheelite type crystal phase pigment, and by co-doping ions at different lattice positions, the electron structure of the crystal formed by the pigment can be effectively regulated, such that the reflectivity of the crystal on the yellow light and the absorption of the crystal on the blue light can be improved, and the pigment has the bright green phase yellow tone, wherein the L* value, the a* value and the b* value respectively are 90-92, -3 to -6 and 90-92.5; and the yellow inorganic pigment with characteristics of environmental protection, no toxicity, good stability and high performance has good application prospects in the fields of coating materials, plastics, ink and the like, and can replace toxic yellow organic pigments.

The invention discloses a solid phase microextraction fiber for polycyclic aromatic hydrocarbon enriching detection and a manufacturing method thereof, and belongs to the technical field of contaminant detection. The invention provides a method capable of being used for manufacturing a solid phase microextraction coating on different fiber substrates and realizing combined use with gas chromatography or gas chromatography-mass spectrum, and the method is used for polycyclic aromatic hydrocarbon contaminant detection. Metal fiber is used as a substrate; dopamine is polymerized on the surface ofthe substrate so as to provide functional groups for polydopamine; the polydopamine is firstly combined with COF material single ligands so as to provide an anchor point; a PDA-COP composite layer isfinally synthesized and is used for solid phase microextraction. The solid phase microextraction fiber has the advantages that through the great pi bond effects between the solid phase microextraction fiber and the polycyclic aromatic hydrocarbon, the adsorption effect on the polycyclic aromatic hydrocarbon can be enhanced; during the enrichment, a certain separation effect is achieved; the substrate pretreatment step of samples can be effectively simplified; meanwhile, the enriching capability of the polycyclic aromatic hydrocarbon contaminants can be greatly improved; the detection limit ofthe polycyclic aromatic hydrocarbon contaminants can be reduced.

The invention discloses a rapid synthesis method of an indium phosphide polycrystalline material, which comprises the following steps of: (I) performing surface cleaning treatment on indium; (II) placing a multi-tubular quartz phosphorus bubble with phosphorus into a phosphorus source furnace; (III) placing the pre-designed thermal insulation system, heater, crucible with indium, phosphorus source furnace and seed crystal and B2O3 into a high-pressure single-crystal furnace hearth; (IV) vacuumizing the inside of the furnace and filling high-purity argon; (V) heating to vaporize phosphorus in the phosphorus bubble and injecting into indium melt, and reacting to generate indium phosphide; and (VI) growing crystal. The multi-tubular quartz phosphorus bubble comprises a quartz phosphorus container, at least two quartz phosphorus bubble tubes and a quartz cover. By adopting a multi-tubular quartz phosphorus bubble, the method disclosed by the invention realizes a rapid multi-tubular phosphorus injection synthesis technology, solves the problems of long synthesis time, non-uniform melt proportioning, impurity pollution and the like in the original technology, realizes rapid, efficient and high-purity synthesis of the indium phosphide material, and performs InP single crystal growth more easily.

A geldanamycin derivate with nucleoside base is prepare by inducing soluble nucleoside by geldanamycin and obtaining the final product. Nucleoside base is connected with geldanamycin on Linker. It can keep or strengthen antiviral activity of geldanamycin and improve solubility and tissue distribution.

The invention discloses a synthesizing method of cadmium selenide quantum point through microbe cell, which comprises the following steps: A. A. preparing microbe cell; B. selenidizing the microbe cell; C. cadmating the cell to culture continuously; D. extracting CdSe quantum point from cell; E. purifying the CdSe quantum point. The invention simplifies the operation without organic metal compound and inert gas to protect, which is beneficial to do industrialization synthesis of nanometer particle (quantum point).

The invention provides a preparation method for a grafted and modified silicon-based solid-state-amine carbon dioxide adsorption material. The preparation method comprises the following steps: respectively grafting a silane coupling agent-diethylenetriamino propyl trimethoxy silane with a high content of amine to four types of silicon dioxide base bodies in a post-period grafting and modifying manner to synthesize a solid adsorption material; adsorbing carbon dioxide by utilizing the solid adsorption material; and forming a stable silica silicon bond between the silane coupling agent and each silicon dioxide base body by chemical reaction between methoxy in the silane coupling agent and hydroxyl on each silicon dioxide base body, so as to firmly graft the silane coupling agent to the surface of silicon dioxide and synthesize the stable carbon dioxide adsorption material; the adsorption material prepared in the manner has the good heat stability and the high mass transfer efficiency; the carbon dioxide can be efficiently captured.

The invention discloses methyl phenyl vinyl borosilicate resin and a preparation method and application thereof. the preparation method of the methyl phenyl vinyl borosilicate resin comprises the following steps: dissolving raw materials (including trifunctional alkoxy silane, bifunctional alkoxy silane, boric acid or boron halide, a double-end capping agent or unifunctional alkoxy silane) into a solvent according to a certain ratio; under the action of strong acid, introducing nitrogen gas for protection and carrying out hydrolytic polycondensation for 4-8h; then washing with water and separating liquid; recycling the solvent under reduced pressure; and finally removing low-boiling-point substances in vacuum at a temperature of 145-175 DEG C under a pressure of lower than -0.095MPa to obtain the methyl phenyl vinyl borosilicate resin. The prepared methyl phenyl vinyl borosilicate resin has the advantages of high light transmittance, no yellowing, strong caking property, good high-temperature resistance and high tensile strength and can be applied to the field of LED packaging material.

The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 1,3-cyclohexanedione. The preparation method of the 1,3-cyclohexanedione comprises the following steps: with 1,3-acetonedicarboxylic ester and acrylate as raw materials, carrying out condensation and cyclization under the action of a base catalyst to prepare an intermediate; carrying out hydrolysis decarboxylation on the intermediate to obtain a crude product; and recrystallizing the crude product to obtain the 1,3-cyclohexanedione. The preparation method of the 1,3-cyclohexanedione hasthe advantages that process conditions are convenient to realize, post-treatment operation process is simple, yield is as high as 90.9%, reaction selectivity is high, production efficiency is high, operation safety is high, pollution is small, and the preparation method is suitable for industrial scale production.

The invention discloses a continuous synthesis method of a graphene / ferrite nanocomposite. According to the synthesis method, the graphene / ferrite nanocomposite is prepared by taking graphene, sodium hydroxide aqueous solution and ferric salt solution or ferric salt solution doped with nickel salt and zinc salt and adopting a reverse co-precipitation method. By adopting the synthesis method, continuous synthesis of the nanocomposite is realized by continuous material injection and continuous magnetic separation and output of products, obtained ferrite and graphene are mixed evenly and are combined firmly, and an excellent absorbing property is achieved. Therefore the synthesis method has the advantages of continuous synthesis capability, low synthesis temperature, low energy consumption, low cost and quantity production capability, and has better application prospect.

The invention provides modified white latex and a preparation method thereof. The modified white latex is prepared from, by weight, 100 parts of monomer mixture, 5-10 parts of protective colloid, 0.2-5.0 parts of chain transfer agent, 1.0-5.0 parts of plasticizer, 0.6-1.2 parts of emulsifier, 1.0-2.0 parts of buffering agent, 0.6-0.9 part of initiator and 100-120 parts of water. The monomer mixture comprises main monomers and functional monomers. The weight of main monomers accounts for 80%-95% of the total quantity of the monomer mixture. The main monomers are vinyl acetate, and the functional monomers comprise iso-octyl acrylate and vinyl versatate. The water tolerance and bonding performance of the white latex are improved, and the prepared white latex has the advantages that a coating is good in water tolerance and high in bonding strength.

An adsorbent / decomposing material having a (titanium oxide)-zeolite complex skeleton can be produced through the following steps (A) and (B): (A) treating a mixture containing an aluminum component and a silicon component and having a chemical composition from which titanium oxide and zeolite can be formed with an alkali containing an alkali metal ion to produce a (titanium oxide)-zeolite complex having a photocatalytic activity; and (B) immersing the (titanium oxide)-zeolite complex produced in step (A) in a solution containing a silver ion to cause the substitution of the alkali metal ion in the (titanium oxide)-zeolite complex by the silver ion through ion exchange.

The invention provides a thermally activated delayed fluorescence luminescent material constructed based on a nitrogen-containing hetero-helicene mother nucleus and applications of the thermally activated delayed fluorescence luminescent material in electroluminescent devices. The invention has the obvious characteristics that: 1) sulfonyl and carbonyl are very good acceptor units in TADF materials, but no sulfonyl and carbonyl double acceptor units exist in one TADF molecule at the same time; the helicene containing heteroatoms has a relatively large helical curvature; 2) directly construction of an MR-TADF material by utilizing the nitrogen hetero helicene parent nucleus is realized; 3) a TICT-TADF material is constructed by taking the nitrogen hetero helicene parent nucleus as a receptor unit, and hanging a donor unit at the periphery; and 4) the novel TADF (including MR-TADF and TICT-TADF) material can cover emission regions such as blue light, green light, red light-near infraredlight and even single-molecule white light. The nitrogen-containing hetero-helicene parent nucleus has the advantages of novel receptor, different TADF construction modes, wide color gamut and the like.

The invention discloses a sensitive probe as well as a preparation method and a method for detecting salmonella enteritidis by virtue of the sensitive probe, relates to a probe, a preparation method and application of the probe, and aims to solve the problems of high cost, instability, high deactivation rate of an antibody and poor sensitivity of an existing probe. The sensitive probe is prepared from antibiotics and a signal carrier. The preparation method comprises the following steps: 1, preparing yellowish-brown emulsion; 2, preparing a carboxylated immunomagnetic bead; 3, preparing an activated magnetic microsphere; 4, adding a resuspension solution for storage. The method for detecting the salmonella enteritidis by virtue of the sensitive probe comprises the following steps: 1, preparing an immunochromatographic test strip for the salmonella enteritidis; 2, mixing liquid to be detected and the sensitive probe for incubation, adding dropwise a mixed solution onto a sample pad of the immunochromatographic test strip for the salmonella enteritidis, performing reaction for 10 minutes, and reading a result. According to the sensitive probe, the preparation method and the detection method, only one antibody is struck on a nitrocellulose membrane for direct detection, so that the cost is greatly reduced, and simplicity and convenience are achieved; the sensitive probe, the preparation method and the detection method are applied to detection of the salmonella enteritidis.

The invention discloses a cultivation method for inducing scutellaria baicalensis hairy root based on agrobacterium rhizogenes infection, which uses an agrobacterium rhizogenes bacteria liquid to infect root of a scutellaria baicalensis explant and induces the scutellaria baicalensis explant to form a hairy root, the scutellaria baicalensis hairy root presents yellow hairy on a MS solid medium, so that scutelloside can be stably synthesized, an ITS sequencing is performed and the hairy root can be identified as the scutellaria baicalensis hairy root of a scutellaria. Then seed selection is performed for further in a seed selection medium and a cultivation condition can be optimized to select lines which raise the content of active ingredient scutelloside used for hairy root traditional Chinese medicines. Hairy root can be obtained through scutellaria of a scutellaria introduced by agrobacterium rhizogenes, wherein the inductivity can reach 10 - 40%, the obtained scutellaria baicalensis hairy root presents yellow hairy which is capable of stably synthesizing scutelloside. According to the invention, the scutellaria baicalensis hairy root of a scutellaria is cultivated on the optimized medium, the growth is rapid and the biomass can be increased for 23 -35 times in 30 - 35 days, and the cultivation is performed under the dark conditions. The invention has the characteristics of low energy consumption and low cost, which is suitable for industrialization production.

The invention provides a fluorescence immunoassay method based on carbon quantum dots. The carbon quantum dot is prepared by using citric acid as a carbon source and thiourea or urea as a nitrogen source. The carbon quantum dot is applied to an enzyme-linked immunoassay method. A novel high-sensitivity fluorescence immunoassay method based on carbon quantum dots is established. An efficient fluorescence internal filtration effect is generated between carbon quantum dots and an enzyme-catalyzed chromogenic substrate, and an absorbance signal formed by reaction of horse radish peroxidase / alkaline phosphatase catalytic substrate in enzyme-linked immunoassay can be successfully and effectively converted into a fluorescence signal. The method has the advantages of simplicity in operation, low cost, high sensitivity, good stability and the like, and can be used for quantitative detection of the micromolecular hapten. In addition, the method has good expansibility and is expected to be expanded to other target detection systems.

A synthetic process for gem grade diamond comprises the following steps: (1) placing an assembled synthetic block in a high pressure chamber of a cubic press; after pressurizing the synthetic block to a final pressure of 90-95 MPa at one time, maintaining the pressure; when the pressure rises to 40-50% of the final pressure, starting heating and enabling the heating power to rise to 4-5 kw within 10-15 s; after preserving the heat of the synthetic block for 3-5 min, increasing the heating power to 9-10 kw for heat preservation; (2) after preserving the heat of the synthetic block for 5-10 h, entering a continuous heat preserving and pressure maintaining stage after continuous temperature increasing, heat preserving, pressure increasing and pressure maintaining; (3) after continuous heat preservation, stopping heating and cooling the synthetic block to room temperature; releasing the pressure when the temperature is halved; finishing the process till the pressure is released to normal pressure. The synthetic process for the gem grade diamond is especially suitable for multi-crystal-seed synthetic processes, can reasonably supply enough carbon source according to the growing speeds of crystal seeds in the control process and can enable the crystal seeds to stably grow for a long time without being affected by spontaneous nucleation to synthesize large particle size and inclusion-free high-quality diamond single crystal; the crystal is colorless and transparent and the quality of the crystal is good; the synthetic process for the gem grade diamond can realize mass production and low production cost.

The invention relates to an amphoteric ionic antistatic agent for acrylonitrile butadiene styrene (ABS) and a preparation method of the antistatic agent. The efficient amphoteric ionic high molecular antistatic agent is synthesized from three monomers, namely methyl acrylyl ethyl trimethyl ammonium chloride, sodium p-styrene sulfonate and styrene, by virtue of a free radical emulsion copolymerization process. Applied to an ABS material, the amphoteric ionic antistatic agent prepared by the invention has the advantages of being low in surface resistance, durable in antistatic action, light in color and good in heat resistance; the surface resistivity of the ABS material is reduced to 106-107 omega; the antistatic effect is significantly improved compared with those of conventional small molecular and high molecular antistatic agents; and the antistatic agent disclosed by the invention is easy to synthesize, free from toxicity and pollution, moderate in cost and good in application prospect.

An illumination device (1) comprising: at least one light emitting device (5); and a suspension structure (2), suspending the at least one light emitting device (5) in a desired position. Further, the illumination device (1) has a transducer (6), adapted to generate pressure waves at a drive frequency; wherein the suspension structure (2) is utilized as a flow guiding structure (7), having a first end adapted to receive the pressure waves from the transducer, and a second end adapted to generate a pulsating net output flow towards the at least one light emitting device (5), thereby cooling the at least one light emitting device (5). By utilizing the suspension structure itself as flow guiding structure cooling can be integrated in a cost efficient way. Further, no additional space is required to accommodate the flow guiding structure.

The invention discloses a method for synthesizing CsPbI3 perovskite nanocrystals by using a room-temperature non-polar solvent system. The method comprises the following steps: dissolving lead iodideand tetraoctylammonium iodide in toluene to form a lead precursor, dissolving a cesium salt in a long-chain organic acid to obtain a cesium precursor, injecting the cesium precursor into the lead precursor, carrying out a reaction, adding an iodine-rich ligand toluene solution, and purifying the mixed solution with a flocculant to obtain the CsPbI3 nanocrystal. According to the method, under the condition of room temperature, an iodine-rich ligand passivation method is adopted in a toluene solution, so that the gamma-CsPbI3 nanocrystalline which is low in cost, high in yield and high in quality is stably synthesized at room temperature.

The invention discloses a modified composite fiber membrane for oil-water separation, and a preparation method thereof. The preparation method comprises the following steps: mixing a PAN-containing solution with an MOFs-containing solution to obtain a membrane casting solution, and electrospinningthe membrane casting solution to obtain a base membrane; and drying the base membrane, and coating thebase membrane with fluorosilane steam to obtain the nanofiber membrane, wherein the membrane casting solution includes 5-12 wt% of PAN, 0.2-1 wt% of MOFs and 87-94.8 wt% of a polar solvent; and the MOFs are NH2-UIO-66(Zr). The preparation method has the advantages of simplicity in operation, go film-forming property, and uniform distribution of the MOFs material in the fiber, the water contact angle of the surface of the membrane is 150.4 DEG and reaches a superhydrophobic condition, the adsorption capacity of the composite fiber membrane to silicone oil reaches 33.7 g / g, the oil flux of dichloromethane separation under the action of gravity is 2286 L.m<-2>h<-1>, the separation efficiency exceeds 99.8%, the oil flux after ten cycles is still kept at 1792 L.m<-2>h<-1>, and the composite fiber membrane is used for efficient oil-water separation.

The invention relates to aluminosilicate chabazite with medium silica-alumina ratio. The molar ratio of silicon atoms to aluminum atoms of the aluminosilicate chabazite is 20-40, the aluminosilicate chabazite is prepared from compounds of an aluminum source and a silicon source, sodium hydroxide, potassium hydroxide and a buffer agent according to the molar ratio as follows: Na2O: K2O: the buffer agent: Al2O3: SiO2: H2O= (2-20): (2-20): (2:20): 1: (40-80): (300-800), the buffer agent is one or two of sodium bicarbonate and sodium carbonate, and then the aluminosilicate chabazite is loaded with copper ions to obtain an internal combustion engine tail gas cleaning treatment catalyst. Chabazite is convenient to synthesize. The catalyst has catalytic activity on desorption of oxynitride from internal combustion engine tail gas by selective reduction; and after the catalyst is aged, the activity of the catalyst is still above 90%.

The invention provides a method for direct hydrothermal synthesis of chabasite with an intermediate silica-alumina ratio. The method is characterized by comprising the steps that in a reaction for synthesizing the chabasite under the hydrothermal condition, no organic template is added, no chabasite seed crystal is added, alkalescent inorganic salt is added, and an aluminosilicate zeolite molecular sieve with a chabasite structure is obtained; reacting matter for preparing hydrogel is prepared from, by molar ratio, 1-20 parts of Na2O, 2-30 parts of K2O, 0.05-8.0 parts of alkalescent inorganic salt, 1 part of Al2O3, 8-80 parts of SiO2 and 150-800 parts of H2O. According to the method, the zeolite molecular sieve with the chabasite structure can be synthesized stably without using template or fluorochemicals or seed crystals.

The present invention relates to methods of using synthetic lethal screening techniques to identify drug targets. The methods of the present invention use "barcoded" libraries of cells, where the library consists of a collection of different mutant clones, each mutant clone bearing a knock-out mutation of a different gene. Each mutant clone has a unique DNA identifier tag, or "barcode," to allow for quick and convenient identification of the clone and its mutation. The use of such a library allows for rapid, quantitative, sensitive and simple identification of genes which interact with a mutated target gene. So identified genes are promising targets for drug screening.

The invention provides square acid derivate and pharmaceutical salt thereof. The square acid derivate has a structure shown as the formula (I). The square acid derivate can be taken as micro-molecular tubulin inhibitor, having the function of resisting microtubule and remarkable anti-tumor activity and the advantages of small molecular weight, simple synthesis and small toxic and side effects. The invention further provides a synthesis method of the square acid derivate and an anti-tumor medical composite taking the square acid derivate and the pharmaceutical salt thereof as active components.

The invention discloses a method of synthesizing CdSe quantum dots with Amino acid and polypeptide, comprising the following steps: A, preparing cell-free system of selenium-containing amino acid; B, preparing Cd-glutathione; C, synthesizing CdSe quantum dots. The invention is provided with a simple technology and mild reaction conditions. As no organometallic compounds are included in the preparation, the protection from the inert gas is not needed. The production is safe and low in cost, helpful to the industrial synthesis of the nano-particles (including quantum dots).