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Rhizoma corydalis extract as well as preparation method and use thereof

An extract, Yuanhu technology, applied in the field of medicine, can solve the problem of unreported Yuanhu single-flavor medicinal materials, etc., and achieve the effects of stable method, strong operability, and controllable results.

Inactive Publication Date: 2013-07-10
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the traditional Chinese medicine Yuanhu has been used in combination with other traditional Chinese medicines to treat depression, but there is no report on the use of Yuanhu single herb in the treatment of depression.

Method used

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  • Rhizoma corydalis extract as well as preparation method and use thereof
  • Rhizoma corydalis extract as well as preparation method and use thereof
  • Rhizoma corydalis extract as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, the preparation of Yuan Hu extract

[0024] 1. Materials:

[0025] Yuanhu medicinal materials were purchased from Hebei Anguo Chinese Medicinal Materials Co., Ltd., produced in Hebei Province, and complied with the relevant regulations of the medicinal materials in the first text of the Pharmacopoeia of the People's Republic of China in 2005. The samples were stored in the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, with batch number yp0033. After identification, the name of each medicinal material is consistent with the actual product, and the quality is in line with the Pharmacopoeia standard. Ethanol (Jinan Huifengda Chemical Development Co., Ltd.); purified water (Hangzhou Wahaha Group Co., Ltd.); AB-8 macroporous resin (Tianjin Nankai University Chemical Plant); X-5 macroporous resin (Tianjin Nankai University Chemical Plant) ; D101-1 macroporous resin (Anhui Samsung Resin Technology Co., Ltd.).

[0026] 2. Method...

Embodiment 2

[0063] Example 2, Determination of the content of total alkaloids in the extract of Rhizoma Rhizoma Rhizoma Rhizoma and its methodological investigation

[0064] Modern pharmacological studies have shown that the main effective components of Rhizoma Rhizoma are the total alkaloids of Rhizoma Rhizoma Rhizoma. Among various tetrahydroisoquinoline alkaloids, tetrahydropalmatine exhibits the strongest physiological activity. Therefore, with reference to relevant literature (Wang Xuying et al., Research on the extraction and purification process of Corydalis total alkaloids [J], Chinese patent medicine, 2010, 32 (11): 1899-1903), the present invention selects bromocresol green acid dye colorimetric method Determination of the content of total alkaloids in the extract of Rhizoma chinensis. The principle of this method is that in a certain pH medium, organic alkaloids can quantitatively combine with certain acid dyes to form colored complexes. The colored complex can be quantitativ...

Embodiment 3

[0093] Embodiment 3, the pharmacodynamic experiment of the antidepressant effect of the extract of Yuanhu

[0094] Mouse tail suspension test (tail suspension test, TST) and forced swimming (forced swimming test, FST) experiment are both common animal experiment methods to verify whether the drug has antidepressant activity, so the present invention uses the above two experiments to investigate the present invention The effect of the extract of Yuan Hu on a mouse model of depression. However, in TST and FST experiments, certain drugs (particularly psychomotor stimulants) that shorten immobility time by stimulating locomotor activity can lead to false positive results. Therefore, it is necessary to observe the changes in the number of locomotor activities in mice before and after administration through locomotor activity test (LAT), so as to rule out the possibility that the experimental results are false positives.

[0095] 1. Materials:

[0096] 1.1 Experimental animals:

...

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Abstract

The invention relates to a rhizoma corydalis extract as well as a preparation method and a use thereof. Specifically, the invention relates to the rhizoma corydalis extract containing at least 40% of total alkaloids, an extraction and separation method for preparing the extract, a pharmaceutical composition containing the extract and the use of the extract or the pharmaceutical composition in preparation of medicaments for preventing and / or treating depression.

Description

technical field [0001] The invention relates to the technical field of medicine. Specifically, the present invention relates to a total alkaloid extract of Rhizoma chinensis and its preparation method and antidepressant use. Background technique [0002] Depressive disorder is a type of mood disorder characterized by depressed mood. It is manifested as long-lasting depressed mood, and this mood obviously exceeds the necessary limit, lacks self-confidence, and feels that the energy of the body is obviously reduced. experience joy in activities. Such disorders can also cause physical dysfunction in patients, such as sleep disturbance or loss of appetite. [0003] The incidence of depressive disorder is very high worldwide, almost 2 out of 10 adults have corresponding symptoms, and the age of onset is getting earlier and the incidence is increasing year by year. Therefore, depressive disorder is also called For "spiritual cold". The lifetime prevalence rate of this disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P25/24
Inventor 杨洪军许海玉李春黄璐琦
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI