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Cell or microparticle adsorption fixation device designed and made from hollow optical fiber

A technology of hollow-core optical fiber and tiny particles, which is applied in enzymology/microbiology devices, biochemical cleaning devices, nanostructure manufacturing, etc., can solve the problems of high price and easy leakage, and achieve simple structure, low price, high The effect of resolution

Inactive Publication Date: 2013-07-24
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are very few equipments in this area. The relatively mature equipment is produced by Eppendorf in Germany. However, this equipment uses plastic thin tubes to connect the microtubes and negative pressure adsorption devices, which is easy to leak liquid. In addition, microtube tips need to be prepared. , preparation requires special equipment, etc., and the price is higher

Method used

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  • Cell or microparticle adsorption fixation device designed and made from hollow optical fiber
  • Cell or microparticle adsorption fixation device designed and made from hollow optical fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Under the observation of the microscope, through the multi-dimensional moving platform, make one end of the hollow core fiber close to the cells or tiny particles, fine-tune the hydraulic fine-tuning device at the other end of the hollow-core fiber, and then use the connected hydraulic micro-knob to suck the hollow-core fiber Liquid (such as oil or water) enables one end of the hollow-core optical fiber to absorb cells or tiny particles under the action of tiny negative pressure, and other operations can be performed.

Embodiment 2

[0017] Under the observation of the microscope, through the multi-dimensional moving platform, make one end of the hollow-core fiber close to the cells or small particles, fine-tune the syringe at the other end of the hollow-core fiber, and then use the connected syringe to aspirate other hollow-core fiber (such as air). ), so that one end of the hollow-core optical fiber can absorb cells or tiny particles under the action of tiny negative pressure, and other operations can be performed.

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PUM

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Abstract

The invention relates to a cell or microparticle adsorption fixation device designed and made from a hollow optical fiber. The device includes the hollow optical fiber and a hydraulic or pneumatic negative pressure apparatus. One end of the hollow optical fiber is made into a superfine straw tip, and the other end is in sealing connection with the hydraulic or pneumatic negative pressure apparatus. The cell or microparticle adsorption fixation device designed and made from the hollow optical fiber involved in the invention has the advantages of simple structure, easy manufacturing and manipulation, high sensitivity, high resolution, as well as low price.

Description

Technical field [0001] The invention relates to an adsorption and fixing device for cells or tiny particles designed and manufactured by using hollow-core optical fibers. Background technique [0002] In recent years, in biomedical research and applications, cells often need to be adsorbed and fixed before further micromanipulation. In addition, the development of micro-nano technology and micro-particles also require fixed operations. Therefore, the need for equipment capable of manipulating, adsorbing and fixing small particles has increasingly become a demand hotspot. At present, there are few equipments in this area. The more mature equipment is produced by Eppendorf, Germany. However, this equipment uses plastic thin tubes to connect the microtubes and the negative pressure adsorption device, which is easy to leak. In addition, it is necessary to prepare microtube tips. , Preparation requires special equipment, etc., and the price is relatively high. [0003] The invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00B82B3/00
Inventor 刘书朋陈振宜耿倩倩戴张敏颜发明陈娜郭强文建湘
Owner SHANGHAI UNIV