Device and method for preparing sustainable-released antibacterial real-silk braided suture line

Abstract

The invention provides a device and a method for preparing a sustainable-released antibacterial real-silk braided suture line. The method comprises the following steps of dissolving a macromolecule absorbable material in a corresponding solvent to prepare a solution, and adding the powder of fluoroquinolones into the solution to prepare a coating material for later use; and adding the coating material into a first immersing groove and a second immersing groove of the device for preparing the antibacterial real-silk braided suture line, and performing coating processing on the real-silk braided suture line for at least one time by using the device for preparing the antibacterial real-silk braided suture line, wherein the process of performing coating processing comprises the steps of sequentially allowing the real-silk braided suture line to pass through a first immersing roller, a first pressure roller, a first guide roller, a second immersing roller, a second pressure roller, a second guide roller and a third guide roller, and finally winding the real-silk braided suture line on a roller drum. Aantibacterial agents of the antibacterial real-silk braided suture line are uniformly dispersed in the macromolecule absorbable material and are released gradually with the degradation of the macromolecule absorbable material, so that a sustainable-releasing effect is achieved, and the antibacterial lasting time accords with the healing time of a skin wound.

Description

technical field [0001] The invention relates to a preparation device and method of an antibacterial silk braided suture with long-acting slow-release effect. Background technique [0002] Braided silk suture is a widely used suture material in modern surgery, especially in vascular ligation, gastrointestinal surgery, fascia and skin suture. Silk sutures can not only provide the amino acids needed by the human body, are harmless to the human body, but also have better flexibility than chemical fiber materials. The woven silk sutures avoid the kink phenomenon of traditional twisted silk threads, and are easy to thread and knot during surgery. , Excellent knot holding performance. [0003] Silk braided sutures also have certain disadvantages in surgery. Silk fibroin is a protein fiber that can provide nutrients for the growth and reproduction of microorganisms, and its stability to microorganisms is poor. Although silk braided sutures are sterilized by high temperature befor...

AI Technical Summary

Problems solved by technology

[0004] At present, some research has been devoted to the development of antibacterial sutures and achieved corresponding results. For example: (1) The Vicryl antibacterial sutures developed by Johnson & Johnson are endowed with antibacterial properties by coating on PGLA910 sutures. A broad-spectrum antibacterial agent——IRGACARE MP* (one of the highest purity triclosan, Triclosan), is added to the suture. The suture is non-toxic and non-irritating, and will not adversely affect the wound healing process. 11 days, but because the price is relatively high, it is still difficult to apply widely in China's suture market; CN102726448A), is that suture thread is dipped in silver-containing solution, sprayed, plated and other methods make the suture thread attached with silver element and have antibacterial property, but on the one hand, its operation is comparatively complicated, because silver ion antibacterial agent is in the preparation process , easy to oxidize and reduce the antibacterial performance, on the other hand, chemical reagents such as ammonia may be involved in the operation process, causing environmental pollution, which is not conducive to the health of the operator; (3) Chinese herbal antibacterial sutures, such as Chinese patent (publication number CN101584878A and Publication No. CN101584595A), utilize the antibacterial properties of traditional Chinese medicine, impregnate or coat the suture with traditional Chinese medicine to have antibacterial properties, but the antibacterial sustained release effect of this process is still insufficient, and cannot match the wound healing cycle

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