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Edible buccal patch for treating dental ulcer

A technology for buccal patches and oral ulcers, which is applied in the field of buccal patches to achieve good adhesion, promote wound healing, and improve immunity.

Active Publication Date: 2014-11-19
HAINAN GUANGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report that it is used to prepare oral patch products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of edible buccal patch for the treatment of oral ulcers

[0028] Prepare the culture medium, inoculate Acetobacter xylinum after sterilization, ferment for 2 days at 28°C with a shallow plate static fermentation method, and then wash and purify repeatedly with weak alkali and deionized water to make a biological cellulose film; through mechanical compression method The biocellulose membrane is partially dehydrated to a water content of 50% to obtain a partially dehydrated biocellulose membrane. .

[0029] Get chlorhexidine, gentamicin sulfate and levamisole to be dissolved in water, make the western medicine liquid that concentration is 0.5ppm;

[0030] Take 8 parts by weight of dandelion, 10 parts by weight of licorice, 5 parts by weight of Houttuynia cordata, 3 parts by weight of cork cork, 1 part by weight of forsythia, 1 part by weight of reed root, 5 parts by weight of mulberry leaves, 2 parts by weight of tangerine peel, and 1 part by weigh...

Embodiment 2

[0034] Embodiment 2: Preparation of edible buccal patch for treating oral ulcer

[0035] Prepare the culture medium, inoculate Gluconacetobacter xylinum after sterilization, ferment for 1 day at 30°C by static fermentation in a flat plate, and then repeatedly wash and purify with weak alkali and deionized water to make a biocellulose film; The biocellulose membrane was partially dehydrated to a water content of 40% by a low-temperature drying method to obtain a partially dehydrated biocellulose membrane.

[0036] Aureomycin, amoxicillin, nitrofurazone, levamisole and lysozyme were dissolved in water to make a western medicine solution with a concentration of 1 ppm;

[0037] Take 10 parts by weight of dandelion, 5 parts by weight of licorice, 6 parts by weight of Houttuynia cordata, 5 parts by weight of cork cork, 2 parts by weight of forsythia, 1 part by weight of reed root, 6 parts by weight of mulberry leaves, 1 part by weight of tangerine peel, and 1 part by weight of jujub...

experiment example

[0042] A total of 18 patients with oral ulcers were selected as the experimental subjects, and they were randomly divided into 3 groups in groups of 6. Wherein the 1st group administers the edible buccal patch for treating oral ulcers in Example 1 of the present invention; the 2nd group uses the edible buccal patch for treating oral ulcers in Example 2; the 3rd group uses directly Partially dehydrated biocellulose membrane (moisture content 15%). Observe the ulcer healing situation every day, record the time when the ulcer completely heals, take the average value as the healing time, and the results are shown in the following table:

[0043] group Group 1 Group 2 Group 3 Healing time (days) 4.1 3.7 8.8

[0044] It can be seen that using the edible buccal patch for treating oral ulcers of the present invention can make ulcers heal quickly, and has the technical effect of treating oral ulcers.

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PUM

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Abstract

The invention relates to a buccal patch, and in particular relates to an edible buccal patch for treating dental ulcer. The edible buccal patch is prepared by the steps of: partially dewatering a bio-cellulose membrane, soaking in a liquid medicine and then drying at low temperature. The edible buccal patch contains Western medicine liquid, traditional Chinese medicine liquid and vegetable juice. The product disclosed by the invention has good paste property, can play good adhesion effect even if various chemical binders are not added, can control slow release of the liquid medicine, and prolongs the action time of the product. The edible buccal patch can be directly eaten, or even has the health-care function. Therefore, the product does not damage a human body even if being used at night long or eaten by a consumer by an error. The edible buccal patch also adopts a combined treatment mode of traditional Chinese medicine and western medicine, and has good treatment effect.

Description

technical field [0001] The invention relates to a buccal patch, in particular to an edible buccal patch for treating oral ulcers. Background technique [0002] Oral ulcer (OU), also known as "oral ulcer", is a common oral mucosal disease. It is a depression formed by the integrity of the oral mucosal epithelium, which is continuously damaged or destroyed, and the surface layer is necrotic and exfoliated. The etiology is relatively complex, which may be closely related to the abnormal immune response of the mucosal epithelium and the dysfunction of protective reconstruction after mucosal injury. A large number of studies have shown that the pathogenesis of OU is related to the following factors: genetics, immune disorders, trauma, viral or bacterial infections, autoimmunity, gastrointestinal diseases, anemia, endocrine disorders, nutritional deficiencies, and mental stress. The incidence of OU is very high, and the incidence rate of the general population can be as high as m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/70A61K36/899A61K38/47A61P1/02A61K35/37A61K35/64A61K31/345A61K31/429A61K31/43A61K31/155A61K31/7036A61K35/57
Inventor 钟春燕其他发明人请求不公开姓名
Owner HAINAN GUANGYU BIOTECH
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